Is there A Role for Alpha-Linolenic Acid in the Fetal Programming of Health?

被引：12

作者：

Leikin-Frenkel, Alicia I. ^{[1
,2
]}

机构：

[1] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel

[2] Bert Strassburger Lipid Ctr, IL-52621 Ramat Gan, Israel

来源：

JOURNAL OF CLINICAL MEDICINE | 2016年 / 5卷 / 04期

关键词：

alpha linolenic acid; maternal diet; fetal programming; metabolic syndrome; gene expression; 3 fatty acids; POLYUNSATURATED FATTY-ACIDS; METABOLIC SYNDROME; DOCOSAHEXAENOIC ACID; CARDIOVASCULAR-DISEASE; EICOSAPENTAENOIC ACID; PREGNANCY OUTCOMES; HEART-DISEASE; OMEGA-3-FATTY-ACIDS; WOMEN; NUTRITION;

D O I：

10.3390/jcm5040040

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The role of 3 alpha linolenic acid (ALA) in the maternal diet during pregnancy and lactation, and its effect on the prevention of disease and programming of health in offspring, is largely unknown. Compared to ALA, 3 docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids have been more widely researched due to their direct implication in fetal neural development. In this literature search we found that ALA, the essential 3 fatty acid and metabolic precursor of DHA and EPA has been, paradoxically, almost unexplored. In light of new and evolving findings, this review proposes that ALA may have an intrinsic role, beyond the role as metabolic parent of DHA and EPA, during fetal development as a regulator of gene programming for the prevention of metabolic disease and promotion of health in offspring.

引用

页数：10

共 69 条

[31] Effects of an energy-restricted diet rich in plant-derived alpha-linolenic acid on systemic inflammation and endothelial function in overweight-to-obese patients with metabolic syndrome traits
Egert, Sarah
Baxheinrich, Andrea
Lee-Barkey, Young Hee
Tschoepe, Diethelm
Wahrburg, Ursel
Stratmann, Bernd
[J]. BRITISH JOURNAL OF NUTRITION, 2014, 112 (08) : 1315 - 1322
[32] The Evidence for α-Linolenic Acid and Cardiovascular Disease Benefits: Comparisons with Eicosapentaenoic Acid and Docosahexaenoic Acid
Fleming, Jennifer A.
Kris-Etherton, Penny M.
[J]. ADVANCES IN NUTRITION, 2014, 5 (06) : 863S - 876S
[33] The rat as an animal model for fetoplacental development: a reappraisal of the post-implantation period
Fonseca, Bruno M.
Correia-da-Silva, Georgina
Teixeira, Natercia A.
[J]. REPRODUCTIVE BIOLOGY, 2012, 12 (02) : 97 - 118
[34] n-3 fatty acid dietary recommendations and food sources to achieve essentiality and cardiovascular benefits
Gebauer, Sarah K.
Psota, Tricia L.
Harris, William S.
Kris-Etherton, Penny M.
[J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2006, 83 (06) : 1526S - 1535S
[35] Dietary enrichment with alpha-linolenic acid during pregnancy attenuates insulin resistance in adult offspring in mice
Hollander, K. S.
Brami, C. Tempel
Konikoff, F. M.
Fainaru, M.
Leikin-Frenkel, A.
[J]. ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, 2014, 120 (03) : 99 - 111
[36] Hornstra G, 2000, AM J CLIN NUTR, V71, p1262S, DOI 10.1093/ajcn/71.5.1262s
[37] Hu FB, 1999, AM J CLIN NUTR, V69, P890
[38] Essential fatty acid transfer and fetal development
Innis, SM
[J]. PLACENTA, 2005, 26 : S70 - S75
[39] Do fatty acids affect fetal programming?
Kabaran, Seray
Besler, H. Tanju
[J]. JOURNAL OF HEALTH POPULATION AND NUTRITION, 2015, 33
[40] Koren G, 2015, CAN FAM PHYSICIAN, V61, P41

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