Is there A Role for Alpha-Linolenic Acid in the Fetal Programming of Health?

被引：12

作者：

Leikin-Frenkel, Alicia I. ^{[1
,2
]}

机构：

[1] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel

[2] Bert Strassburger Lipid Ctr, IL-52621 Ramat Gan, Israel

来源：

JOURNAL OF CLINICAL MEDICINE | 2016年 / 5卷 / 04期

关键词：

alpha linolenic acid; maternal diet; fetal programming; metabolic syndrome; gene expression; 3 fatty acids; POLYUNSATURATED FATTY-ACIDS; METABOLIC SYNDROME; DOCOSAHEXAENOIC ACID; CARDIOVASCULAR-DISEASE; EICOSAPENTAENOIC ACID; PREGNANCY OUTCOMES; HEART-DISEASE; OMEGA-3-FATTY-ACIDS; WOMEN; NUTRITION;

D O I：

10.3390/jcm5040040

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The role of 3 alpha linolenic acid (ALA) in the maternal diet during pregnancy and lactation, and its effect on the prevention of disease and programming of health in offspring, is largely unknown. Compared to ALA, 3 docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids have been more widely researched due to their direct implication in fetal neural development. In this literature search we found that ALA, the essential 3 fatty acid and metabolic precursor of DHA and EPA has been, paradoxically, almost unexplored. In light of new and evolving findings, this review proposes that ALA may have an intrinsic role, beyond the role as metabolic parent of DHA and EPA, during fetal development as a regulator of gene programming for the prevention of metabolic disease and promotion of health in offspring.

引用

页数：10

共 69 条

[1] Abeywardena Mahinda Y., 2011, Endocrine Metabolic & Immune Disorders-Drug Targets, V11, P232
[2] Novel regulatory roles of omega-3 fatty acids in metabolic pathways: a proteomics approach
Ahmed, Abeer A.
Balogun, Kayode A.
Bykova, Natalia V.
Cheema, Sukhinder K.
[J]. NUTRITION & METABOLISM, 2014, 11
[3] Alfaradhi Maria Z., 2011, Frontiers in Genetics, V2, P27, DOI 10.3389/fgene.2011.00027
[4] Are all n-3 polyunsaturated fatty acids created equal?
Anderson, Breanne M.
Ma, David W. L.
[J]. LIPIDS IN HEALTH AND DISEASE, 2009, 8
[5] Distribution, interconversion, and dose response of n-3 fatty acids in humans
Arterburn, Linda M.
Hall, Eileen Bailey
Oken, Harry
[J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2006, 83 (06) : 1467S - 1476S
[6] Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: Benefits for human health and a role in maintaining tissue n-3 fatty acid levels
Barcelo-Coblijn, Gwendolyn
Murphy, Eric J.
[J]. PROGRESS IN LIPID RESEARCH, 2009, 48 (06) : 355 - 374
[7] FETAL ORIGINS OF CORONARY HEART-DISEASE
BARKER, DJP
[J]. BRITISH MEDICAL JOURNAL, 1995, 311 (6998) : 171 - 174
[8] Effects of a rapeseed oil-enriched hypoenergetic diet with a high content of α-linolenic acid on body weight and cardiovascular risk profile in patients with the metabolic syndrome
Baxheinrich, Andrea
Stratmann, Bernd
Lee-Barkey, Young Hee
Tschoepe, Diethelm
Wahrburg, Ursel
[J]. BRITISH JOURNAL OF NUTRITION, 2012, 108 (04) : 682 - 691
[9] α-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans
Brenna, J. Thomas
Salem, Norman, Jr.
Sinclair, Andrew J.
Cunnane, Stephen C.
[J]. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2009, 80 (2-3): : 85 - 91
[10] Efficiency of conversion of α-linolenic acid to long chain n-3 fatty acids in man
Brenna, JT
[J]. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2002, 5 (02) : 127 - 132

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