Mapping the Estrous Cycle to Context-Specific Extinction Memory

被引:12
作者
Hilz, Emily N. [1 ]
Smith, Ryan W. [1 ]
Hong, Yae Jin [2 ]
Monfils, Marie H. [1 ,3 ]
Lee, Hongjoo J. [1 ,3 ]
机构
[1] Univ Texas Austin, Dept Psychol, 108 East Dean Keeton Stop A8000, Austin, TX 78712 USA
[2] Univ Texas Austin, Intergrat Biol Dept, Austin, TX 78712 USA
[3] Univ Texas Austin, Inst Neurosci, Austin, TX 78712 USA
关键词
estrous cycle; renewal; reinstatement; context; extinction; NUCLEUS-ACCUMBENS; SYNAPTIC PLASTICITY; DORSAL HIPPOCAMPUS; PRELIMBIC CORTEX; NEURAL CIRCUITS; FOOD CUES; FEAR; PROGESTERONE; AMYGDALA; RENEWAL;
D O I
10.1037/bne0000343
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
In Pavlovian renewal paradigms, intact female rats have previously failed to exhibit renewal of appetitive behavior after extinction. However, when treated with exogenous estradiol, female rats exhibit robust renewal behavior. The current study aims to investigate whether the estrous cycle can influence renewal of appetitive behaviors and activity in brain areas known to support the renewal effect. We further aimed to examine whether the estrous cycle would similarly affect renewal of two different types of appetitive behaviors. We first establish that rats in the proestrous stage of the estrous cycle during extinction exhibit elevated renewal behavior compared with rats in either metestrous/diestrous stages, and only rats in proestrus during extinction training (but not during the renewal test) exhibit elevated renewal behavior. Furthermore, we show that this estrous cycle dependent effect on renewal only applies to the conditioned approach behavior toward the food delivery site but not the conditioned approach behavior toward the light cue associated with food delivery. Finally, we examined FOS activity within the prelimbic and infralimbic areas of the medial prefrontal cortex, the dorsal and ventral hippocampal formation, the paraventricular nucleus of the thalamus, the nucleus accumbens, and areas of the amygdala. Particularly in the hippocampus and amygdala, FOS expression which corresponded to the behavioral differences between groups was observed. Results from this study suggest that context information processing may vary as a function of endogenous female hormones across the gonadal hormone cycle and that encoding and retrieval of this information is accomplished in a state-specific manner.
引用
收藏
页码:614 / 623
页数:10
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