Evidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (sALS)

被引：125
作者：
Zhang, RZ
Gascon, R
Miller, RG
Gelinas, DF
Mass, J
Hadlock, K
Jin, X
Reis, J
Narvaez, A
McGrath, MS
机构：
[1] Univ Calif San Francisco, San Francisco Gen Hosp, San Francisco, CA 94110 USA
[2] Calif Pacific Med Ctr, San Francisco, CA 94115 USA
[3] Pathol LLC, Burlingame, CA 94010 USA
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2005年 / 159卷 / 1-2期
关键词：
amyotrophic lateral sclerosis (ALS); Alzheimer's disease (AD); motor neuron disease; immune activation; monocyte/macrophage;
D O I：
10.1016/j.jneuroim.2004.10.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Sporadic amyotrophic lateral sclerosis (sALS) is a progressive neuroinflammatory disease of spinal cord motor neurons of unclear etiology. Blood from 38 patients with sALS, 28 aged-match controls, and 25 Alzheimer's disease (AD) patients were evaluated and activated monocyte/macrophages were observed in all patients with sALS and AD; the degree of activation was directly related to the rate of sALS disease progression. Other parameters of T-cell activation and immune globulin levels showed similar disease associated changes. These data are consistent with a disease model previously suggested for AD, wherein systemic immunologic activation plays an active role in sALS. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：215 / 224
页数：10
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