Copper-Catalyzed Three-Component Synthesis of Benzothiazolethiones from o-lodoanilines, Isocyanide, and Potassium Sulfide

被引：48

作者：

Dang, Pan ^{[1
]}

Zeng, Weilan ^{[1
]}

Liang, Yun ^{[1
,2
]}

机构：

[1] Hunan Normal Univ, Minist Educ, Key Lab Chem Biol & Tradit Chinese Med Res, Natl & Local Joint Engn Lab New Petrochem Mat & F, Changsha 410081, Hunan, Peoples R China

[2] Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 01期

关键词：

DERIVATIVES; EFFICIENT; ACCESS; 2-MERCAPTOBENZOTHIAZOLE; HALOANILINES; REACTIVITY;

D O I：

10.1021/ol503186w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient copper catalyzed strategy for the synthesis of a variety of benzothiazolethione derivatives has been developed. In the presence of CuCl, the three-component reaction of o-iodoanilines and K2S with p-toluenesulfonylmethyl isocyanide proceeded smoothly to obtain the corresponding benzothiazolethiones in good to excellent isolated yields. Notably, isocyanide functioned as a carbon source and K2S functioned as a sulfur source in this reaction.

引用

页码：34 / 37

页数：4

共 32 条

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