Pathogenesis of Gallstones

被引：122

作者：

Venneman, Niels Gerard ^{[1
]}

van Erpecum, Karel Johannes ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, NL-3508 GA Utrecht, Netherlands

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2010年 / 39卷 / 02期

关键词：

Bilirubin; Bile salt; Cholesterol; Crystallization; FXR; Gallbladder; Motility; BILIARY ALPHA(1)-ACID GLYCOPROTEIN; BILE-ACID SYNTHESIS; CHOLESTEROL CRYSTALLIZATION; HUMAN GALLBLADDER; NUCLEATION TIME; LITH GENES; PHENOTYPIC CHARACTERIZATION; DETERMINE SUSCEPTIBILITY; URSODEOXYCHOLIC ACID; DIETARY-CHOLESTEROL;

D O I：

10.1016/j.gtc.2010.02.010

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Cholesterol gallstone formation is a complex process and involves phase separation of cholesterol crystals from supersaturated bile. In most cases, cholesterol hypersecretion is considered the primary event in gallstone formation. The sterol is transported through the hepatocytic canalicular membrane by ABCG5-G8. Expression of this transport protein is regulated by transcription factor Liver X Receptor-alpha, which may be responsible for biliary hypersecretion. Hydrophobic bile salt pool, bile concentration, excess pronucleating mucin, and impaired gallbladder and intestinal motility are secondary phenomena in most cases but nevertheless may contribute to gallstone formation.

引用

页码：171 / +

页数：14

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