Measuring and improving adherence to osteoporosis pharmacotherapy

被引：41

作者：

Cadarette, Suzanne M. ^{[1
]}

Burden, Andrea M. ^{[1
]}

机构：

[1] Univ Toronto, Leslie Dan Fac Pharm, Toronto, ON M5S 3M2, Canada

来源：

CURRENT OPINION IN RHEUMATOLOGY | 2010年 / 22卷 / 04期

基金：

加拿大健康研究院;

关键词：

adherence; compliance; measurement; osteoporosis; persistence; MEDICATION COMPLIANCE; PATIENT ADHERENCE; SELF-REPORT; PERSISTENCE; BISPHOSPHONATE; THERAPY; PRESCRIPTION; FRACTURE; IMPACT; RISK;

D O I：

10.1097/BOR.0b013e32833ac7fe

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of review Osteoporosis is a major public health issue resulting in considerable fracture-related morbidity. Although effective treatment exists, adherence to osteoporosis pharmacotherapy is suboptimal and linked to reduced drug effectiveness. In this paper, we review methods of measuring and improving adherence to osteoporosis pharmacotherapy. Recent findings Most patients will stop osteoporosis pharmacotherapy, yet the majority who discontinue will reinitiate treatment after an extended gap. The key to improving adherence to osteoporosis pharmacotherapy is to reduce the number and length of gaps in treatment. Multifaceted and individualized interventions may help to improve adherence. New strategies aimed at identifying patients likely to stop therapy may also facilitate the development of targeted interventions. Summary Adherence to osteoporosis pharmacotherapy is suboptimal with short periods of persistence and lengthy gaps in therapy. Regular communication regarding the importance of continued therapy is critical. More research to help identify risk profiles of patients likely to become nonadherent, targeted multifaceted interventions to maximize adherence to therapy, and data to support when patients may safely consider a physician directed drug holiday is needed.

引用

页码：397 / 403

页数：7

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