Reaction of 3-azidoisoxazoles with active methylene compounds

被引：9

作者：

Lemport, Pavel S. ^{[1
]}

Roznyatovsky, Vitaly A. ^{[1
]}

Tarasevich, Boris N. ^{[1
]}

Khromova, Olga V. ^{[2
]}

Khrustalev, Victor N. ^{[2
]}

Rozentsveig, Igor B. ^{[3
]}

Nenajdenko, Valentine G. ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119991, Russia

[2] RUDN Univ, Peoples Friendship Univ Russia, Moscow 117198, Russia

[3] Russian Acad Sci, Siberian Branch, AE Favorsky Irkutsk Inst Chem, Irkutsk 664033, Russia

来源：

MENDELEEV COMMUNICATIONS | 2019年 / 29卷 / 05期

基金：

俄罗斯基础研究基金会;

关键词：

REGIOSELECTIVE SYNTHESIS; HETEROCYCLIC-COMPOUNDS; ISOXAZOLE; 1,2,3-TRIAZOLE; CYCLOADDITION; DERIVATIVES; AZIDE; TRANSFORMATIONS; TRIAZINE;

D O I：

10.1016/j.mencom.2019.09.017

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

3-Azidoisoxazoles react with various active methylene compounds (malononitrile, ethyl cyanoacetate and ethyl acetoacetate) in the presence of base to give hybrid isoxazole-triazole molecules in good to nearly quantitative yields.

引用

页码：529 / 530

页数：2

共 30 条

[1]

Banert K, 2010, ORGANIC AZIDES SYNTH, P115

[2] iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLM [J].

Battye, T. Geoff G. ;

Kontogiannis, Luke ;

Johnson, Owen ;

Powell, Harold R. ;

Leslie, Andrew G. W. .

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 2011, 67 :271-281

[3] Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi [J].

Brand, Stephen ;

Ko, Eun Jung ;

Viayna, Elisabet ;

Thompson, Stephen ;

Spinks, Daniel ;

Thomas, Michael ;

Sandberg, Lars ;

Francisco, Amanda F. ;

Jayawardhana, Shiromani ;

Smith, Victoria C. ;

Jansen, Chimed ;

De Rycker, Manu ;

Thomas, John ;

MacLean, Lorna ;

Osuna-Cabello, Maria ;

Riley, Jennifer ;

Scullion, Paul ;

Stojanovski, Laste ;

Simeons, Frederick R. C. ;

Epemolu, Ola ;

Shishikura, Yoko ;

Crouch, Sabrinia D. ;

Bakshi, Tania S. ;

Nixon, Christopher J. ;

Reid, Iain H. ;

Hill, Alan P. ;

Underwood, Tim Z. ;

Hindley, Sean J. ;

Robinson, Sharon A. ;

Kelly, John M. ;

Fiandor, Jose M. ;

Wyatt, Paul G. ;

Marco, Maria ;

Miles, Timothy J. ;

Read, Kevin D. ;

Gilbert, Ian H. .

JOURNAL OF MEDICINAL CHEMISTRY, 2017, 60 (17) :7284-7299

[4] Targeting the Warburg Effect in cancer; relationships for 2-arylpyridazinones as inhibitors of the key glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3) [J].

Brooke, Darby G. ;

van Dam, Ellen M. ;

Watts, Colin K. W. ;

Khoury, Amanda ;

Dziadek, Marie A. ;

Brooks, Hilary ;

Graham, Lisa-Jane K. ;

Flanagan, Jack U. ;

Denny, William A. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 22 (03) :1029-1039

[5] Synthesis of new heterocyclic compounds having 1,2,3-triazole and isoxazole rings in a single molecule [J].

Chen, Qiu ;

Liu, Fangming ;

Xu, Feng ;

Yang, Chun .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2008, 45 (01) :77-83

[6] Recent Advances in Multicomponent Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles [J].

Chen, Zhengkai ;

Liu, Zhubo ;

Cao, Gangjian ;

Li, Hongli ;

Ren, Hongjun .

ADVANCED SYNTHESIS & CATALYSIS, 2017, 359 (02) :202-224

[7] Isoxazolodihydropyridinones: 1,3-Dipolar Cycloaddition of Nitrile Oxides onto 2,4-Dioxopiperidines [J].

Coffinan, Keith C. ;

Hartley, Timothy P. ;

Dallas, Jerry L. ;

Kurth, Mark J. .

ACS COMBINATORIAL SCIENCE, 2012, 14 (04) :280-284

[8] Medicinal attributes of 1,2,3-triazoles: Current developments [J].

Dheer, Divya ;

Singh, Virender ;

Shankar, Ravi .

BIOORGANIC CHEMISTRY, 2017, 71 :30-54

[9] Synthesis and transformations of substituted 4,6-dimethylpyrazolo[3,4-b]pyridyl-3-azides and -sulfonyl chlorides [J].

Dmitrieva, I. G. ;

Dyadyuchenko, L. V. ;

Strelkov, V. D. ;

Kaigorodova, E. A. .

CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2008, 44 (10) :1267-1274

[10] Scaling and assessment of data quality [J].

Evans, P .

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2006, 62 :72-82

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