A mild and highly efficient protocol for the one-pot synthesis of primary α-amino phosphonates under solvent-free conditions

被引：89

作者：

Azizi, N ^{[1
]}

Rajabi, F ^{[1
]}

Saidi, MR ^{[1
]}

机构：

[1] Sharif Univ Technol, Dept Chem, Tehran 11365, Iran

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 50期

关键词：

D O I：

10.1016/j.tetlet.2004.10.092

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Under solvent-free reaction conditions and in the presence of solid LiClO4 a novel and mild protocol for the one-pot, three-component synthesis of primary alpha-amino phosphonates from an aldehyde, hexamethyldisilazane and a trialkyl phosphite is described giving high yields and having short reaction times. The same products are obtained in very low yields, when the three-component reaction is carried out under microwave irradiation and in the absence of solid LiClO4. Examples of some prepared 1-aryl-N,N'-bis(arylidene)inethanediamines are also described. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：9233 / 9236

页数：4

共 38 条

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