GABAA receptor function and pharmacology in epilepsy and status epilepticus

被引：60
|
作者：
Jones-Davis, DM [1 ]
Macdonald, RL
机构：
[1] Univ Michigan, Ann Arbor, MI 48104 USA
[2] Vanderbilt Univ, Dept Neurol, Nashville, TN 37232 USA
[3] Vanderbilt Univ, Dept Mol Physiol, Nashville, TN 37232 USA
[4] Vanderbilt Univ, Dept Biophys, Nashville, TN 37232 USA
[5] Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USA
来源：
CURRENT OPINION IN PHARMACOLOGY | 2003年 / 3卷 / 01期
关键词：
D O I：
10.1016/S1471-4892(02)00015-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
GABA(A) (gamma-n-aminobutyric acid) receptor dysfunction has long been implicated in the development of epilepsy and status epilepticus. Recent advances have been made in understanding the cellular, pharmacological and genetic involvement of GABA(A) receptors in seizure disorders. In particular, genetic mutations found in GABA(A) receptor subunits strongly implicate the GABA(A) receptor in idiopathic generalised epilepsies.
引用
收藏
页码：12 / 18
页数：7
相关论文
共 50 条
  • [41] Spectrum of GABAA receptor variants in epilepsy
    Maljevic, Snezana
    Moller, Rikke S.
    Reid, Christopher A.
    Perez-Palma, Eduardo
    Lal, Dennis
    May, Patrick
    Lerche, Holger
    CURRENT OPINION IN NEUROLOGY, 2019, 32 (02) : 183 - 190
  • [42] Direct Structural Insights into GABAA Receptor Pharmacology
    Kim, Jeong Joo
    Hibbs, Ryan E.
    TRENDS IN BIOCHEMICAL SCIENCES, 2021, 46 (06) : 502 - 517
  • [43] Lability of GABAA receptor function in human partial epilepsy: Possible relationship to hypometabolism
    Pumain, Rene
    Ahmed, Mounia Sid
    Kurcewicz, Irene
    Trottier, Suzanne
    Louvel, Jacques
    Turak, Baris
    Devaux, Bertrand
    Laschet, Jacques
    EPILEPSIA, 2008, 49 : 87 - 90
  • [44] Comparative models of GABAA receptor extracellular and transmembrane domains:: Important insights in pharmacology and function
    Ernst, M
    Bruckner, S
    Boresch, S
    Sieghart, W
    MOLECULAR PHARMACOLOGY, 2005, 68 (05) : 1291 - 1300
  • [45] Extrasynaptic GABAA Receptors: Form, Pharmacology, and Function
    Belelli, Delia
    Harrison, Neil L.
    Maguire, Jamie
    Macdonald, Robert L.
    Walker, Matthew C.
    Cope, David W.
    JOURNAL OF NEUROSCIENCE, 2009, 29 (41): : 12757 - 12763
  • [46] Amino acid tissue levels and GABAA receptor binding in the developing rat cerebellum following status epilepticus
    Lopez-Meraz, Maria-Leonor
    Rocha, Luisa L.
    Miquel, Marta
    Ortega, Jenny C.
    Perez-Estudillo, Cesar A.
    Garcia, Luis I.
    Hernandez, M. E.
    Manzo, J.
    BRAIN RESEARCH, 2012, 1439 : 82 - 87
  • [47] GABAa excitation and synaptogenesis after Status Epilepticus – A computational study
    Keite Lira de Almeida França
    Antônio-Carlos Guimarães de Almeida
    Stephen E. Saddow
    Luiz Eduardo Canton Santos
    Carla Alessandra Scorza
    Fulvio Alexandre Scorza
    Antônio Márcio Rodrigues
    Scientific Reports, 8
  • [48] GABAa excitation and synaptogenesis after Status Epilepticus - A computational study
    de Almeida Franca, Keite Lira
    de Almeida, Antonio-Carlos Guimaraes
    Saddow, Stephen E.
    Canton Santos, Luiz Eduardo
    Scorza, Carla Alessandra
    Scorza, Fulvio Alexandre
    Rodrigues, Antonio Marcio
    SCIENTIFIC REPORTS, 2018, 8
  • [49] Status epilepticus in children with epilepsy: Dutch study of epilepsy in childhood
    Stroink, Hans
    Geerts, Ada T.
    van Donselaar, Cees A.
    Peters, A. C. Boudewijn
    Brouwer, Oebele F.
    Peeters, Els A.
    Arts, Willem F.
    EPILEPSIA, 2007, 48 (09) : 1708 - 1715
  • [50] Status epilepticus in mesial temporal lobe epilepsy
    Yetkin, O.
    Yavuz, E. N. Vanli
    Sirin, N. G.
    Bebek, N.
    Baykan, B.
    EPILEPSIA, 2022, 63 : 266 - 266
12345