GABAA receptor function and pharmacology in epilepsy and status epilepticus

被引：60
|
作者：
Jones-Davis, DM [1 ]
Macdonald, RL
机构：
[1] Univ Michigan, Ann Arbor, MI 48104 USA
[2] Vanderbilt Univ, Dept Neurol, Nashville, TN 37232 USA
[3] Vanderbilt Univ, Dept Mol Physiol, Nashville, TN 37232 USA
[4] Vanderbilt Univ, Dept Biophys, Nashville, TN 37232 USA
[5] Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USA
来源：
CURRENT OPINION IN PHARMACOLOGY | 2003年 / 3卷 / 01期
关键词：
D O I：
10.1016/S1471-4892(02)00015-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
GABA(A) (gamma-n-aminobutyric acid) receptor dysfunction has long been implicated in the development of epilepsy and status epilepticus. Recent advances have been made in understanding the cellular, pharmacological and genetic involvement of GABA(A) receptors in seizure disorders. In particular, genetic mutations found in GABA(A) receptor subunits strongly implicate the GABA(A) receptor in idiopathic generalised epilepsies.
引用
收藏
页码：12 / 18
页数：7
相关论文
共 50 条
  • [21] Pharmacological profile of GABAA receptor subtypes is altered by status epilepticus in the developing rat brain
    Lauren, H.
    Lopez-Picon, F.
    Kukko-Lukjanov, T.
    Uusi-Oukari, M.
    Holopainen, I.
    EPILEPSIA, 2006, 47 : 70 - 71
  • [22] Effects of neonatal status epilepticus and stress on GABAA receptor signaling in the hippocampus: Importance of gender
    Galanopoulou, Aristea
    EPILEPSIA, 2007, 48 : 119 - 119
  • [23] GABAA receptor mutations and epilepsy
    不详
    NEUROSCIENTIST, 2001, 7 (05): : 358 - 358
  • [24] GABAA receptor mutations in epilepsy
    Reid, Christopher A.
    Kullmann, Dimitri M.
    EUROPEAN JOURNAL OF NEUROSCIENCE, 2011, 34 (02) : 235 - 236
  • [25] GABAA receptor epilepsy mutations
    Macdonald, RL
    Gallagher, MJ
    Feng, HJ
    Kang, JQ
    BIOCHEMICAL PHARMACOLOGY, 2004, 68 (08) : 1497 - 1506
  • [26] NMDA receptor activation during status epilepticus is required for the development of epilepsy
    Rice, AC
    DeLorenzo, RJ
    BRAIN RESEARCH, 1998, 782 (1-2) : 240 - 247
  • [27] GABAA Receptor Genetics and Clinical Pharmacology
    Davies P.A.
    Current Anesthesiology Reports, 2014, 4 (1) : 42 - 48
  • [28] A structural perspective on GABAA receptor pharmacology
    Scott, Suzanne
    Aricescu, Alexandru Radu
    CURRENT OPINION IN STRUCTURAL BIOLOGY, 2019, 54 : 189 - 197
  • [29] Refractory status epilepticus in children with and without prior epilepsy or status epilepticus
    Fernandez, Ivan Sanchez
    Jackson, Michele C.
    Abend, Nicholas S.
    Arya, Ravindra
    Brenton, James N.
    Carpenter, Jessica L.
    Chapman, Kevin E.
    Gaillard, William D.
    Gainza-Lein, Marina
    Glauser, Tracy A.
    Goldstein, Joshua L.
    Goodkin, Howard P.
    Helseth, Ashley
    Kapur, Kush
    McDonough, Tiffani L.
    Mikati, Mohamad A.
    Peariso, Katrina
    Riviello, James, Jr.
    Tasker, Robert C.
    Topjian, Alexis A.
    Wainwright, Mark S.
    Wilfong, Angus
    Williams, Korwyn
    Loddenkemper, Tobias
    NEUROLOGY, 2017, 88 (04) : 386 - 394
  • [30] GABAA receptors: structure, pharmacology, and function
    Sieghart, Werner
    AMINO ACIDS, 2009, 37 (01) : 2 - 2
12345