GABAA receptor function and pharmacology in epilepsy and status epilepticus

被引：60
|
作者：
Jones-Davis, DM [1 ]
Macdonald, RL
机构：
[1] Univ Michigan, Ann Arbor, MI 48104 USA
[2] Vanderbilt Univ, Dept Neurol, Nashville, TN 37232 USA
[3] Vanderbilt Univ, Dept Mol Physiol, Nashville, TN 37232 USA
[4] Vanderbilt Univ, Dept Biophys, Nashville, TN 37232 USA
[5] Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USA
来源：
CURRENT OPINION IN PHARMACOLOGY | 2003年 / 3卷 / 01期
关键词：
D O I：
10.1016/S1471-4892(02)00015-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
GABA(A) (gamma-n-aminobutyric acid) receptor dysfunction has long been implicated in the development of epilepsy and status epilepticus. Recent advances have been made in understanding the cellular, pharmacological and genetic involvement of GABA(A) receptors in seizure disorders. In particular, genetic mutations found in GABA(A) receptor subunits strongly implicate the GABA(A) receptor in idiopathic generalised epilepsies.
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页码：12 / 18
页数：7
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