Hypolipidemic effect of proteoglycans isolated from sweet potato (Ipomoea batatas LAM) in hyperlipidemia rats

被引：5

作者：

Kan, Jianquan ^{[1
,2
]}

Shi, Hui ^{[1
,2
]}

Liu, Xiong ^{[1
,2
]}

Chen, Zongdao ^{[1
,2
]}

机构：

[1] Southwest Univ, Coll Food Sci, Chongqing 400715, Peoples R China

[2] Southwest Univ, Chongqing Key Lab Agr Prod Proc, Chongqing 400715, Peoples R China

来源：

FOOD SCIENCE AND BIOTECHNOLOGY | 2014年 / 23卷 / 06期

关键词：

hypolipidemic; proteoglycan; hyperlipidemia; sweet potato; LIPOPROTEIN-LIPASE; CHOLESTEROL; PLASMA;

D O I：

10.1007/s10068-014-0275-1

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Effects of sweet potato proteoglycans (SPG) in rats fed high lipid diets were investigated. Serum lipid indices for SPG were evaluated. SPG had hypolipidemic effects that were correlated with dosage. There were no significant (p > 0.05) differences in hypolipidemic effects between SPG varieties of different molecular weights. SPG-1 (Mw value: 508.3 kDa) significantly (p < 0.05) reduced serum total cholesterol (TC), triacylglyceride (TAG), low density lipoprotein cholesterol (LDL-C), and apolipoprotein (Apo) B levels, and the arteriosclerosis index (AI), and induced serum high density lipoprotein cholesterol (HDL-C), ApoA-I, lecithin cholesterol acyltransferase (LCAT), and liver lipoprotein lipase (LPL) activities, compared with controls. The whole blood viscosity and red blood cell (RBC) membrane microviscosity were also decreased. Hypolipidemic effects were mediated via elevation of the serum HDL-C concentration by induction of LACT activity, an increased ApoA-I concentration, and a reduction in the serum lipid concentration due to regulation of LPL activity.

引用

页码：2021 / 2028

页数：8

共 32 条

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