Risk factors for hepatitis E virus infection and disease

被引:35
|
作者
Kmush, Brittany L. [1 ]
Nelson, Kenrad E. [2 ]
Labrique, Alain B. [1 ,2 ]
机构
[1] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD 21205 USA
[2] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
关键词
asymptomatic infection; epidemiology; hepatitis E; hepatitis E virus; risk factors; severe disease; ORGAN-TRANSPLANT RECIPIENTS; RURAL EGYPTIAN COMMUNITIES; CHRONIC LIVER-DISEASE; SOUTHWEST ENGLAND; SOUTHERN INDIA; HEV INFECTION; IMMUNOGLOBULIN-M; E SEROPREVALENCE; LARGE OUTBREAK; BLOOD-DONORS;
D O I
10.1586/14787210.2015.981158
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Hepatitis E, caused by hepatitis E virus, is a disease of global significance, causing 20 million infections each year. Genotypes 1 and 2 have vastly different epidemiological patterns from genotypes 3 and 4. In genotype 1 and 2 endemic areas, most infections and illness occur in persons 15-30 years of age, with pregnant women being the most likely to experience severe disease. In genotype 3 and 4 endemic areas, most infections and illness occur in those of age 40-60 years, with males representing a large portion of those with severe disease. However, the lack of an easily accessible serologic assay in many countries continues to be a barrier to the diagnosis and recognition of hepatitis E virus.
引用
收藏
页码:41 / 53
页数:13
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