Elevated plasma levels of transforming growth factor (TGF)-β1 and TGF-β2 in patients with disseminated malignant melanoma

被引：121

作者：

Krasagakis, K

Thölke, D

Farthmann, B

Eberle, J

Mansmann, U

Orfanos, CE

机构：

[1] Free Univ Berlin, Univ Med Ctr Benjamin Franklin, Dept Dermatol, D-12200 Berlin, Germany

[2] Free Univ Berlin, Univ Med Ctr Benjamin Franklin, Inst Med Stat, D-12200 Berlin, Germany

来源：

BRITISH JOURNAL OF CANCER | 1998年 / 77卷 / 09期

关键词：

TGF-beta isoform; plasma level; melanoma patients;

D O I：

10.1038/bjc.1998.245

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Overexpression of transforming growth factor-beta isoforms (TGF-beta 1, -beta 2, -beta 3) has been previously reported in human melanoma cell lines and tumours. The aim of the present study was to evaluate the plasma levels of TGF-beta isoforms in melanoma patients. Significantly elevated levels of TGF-beta 1 (4.2 x the controls, P = 0.0094) and of TGF-beta 2 (1.5 x the controls. P = 0.012) but not of TGF-beta 3 were measured in patients with disseminated but not locoregional melanoma. These results indicate systemic circulation of potentially immunosuppressive peptides of the TGF-beta family in end-stage melanoma patients.

引用

页码：1492 / 1494

页数：3

共 2 条

[1] Transforming growth factor beta 1 is significantly elevated in plasma of patients suffering from renal cell carcinoma
Junker, U
Knoefel, B
Nuske, K
Rebstock, K
Steiner, T
Wunderlich, H
Junker, K
Reinhold, D
CYTOKINE, 1996, 8 (10) : 794 - 798
[2] Increased transforming growth factor β1 plasma level in patients with renal cell carcinoma:: A tumor-specific marker?
Wunderlich, H
Steiner, T
Kosmehl, H
Junker, U
Reinhold, D
Reichelt, O
Zermann, DH
Schubert, J
UROLOGIA INTERNATIONALIS, 1998, 60 (04) : 205 - 207

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