Bioavailability, metabolism and physiological impact of 4-oxo-flavonoids

被引：178
作者：
Manach, C
Regerat, F
Texier, O
Agullo, G
Demigne, C
Remesy, C
机构：
[1] INRA,MALAD METAB LAB,F-63122 ST GENES CHAMPANE,FRANCE
[2] FAC PHARM CLERMONT FERRAND,LAB PHARMACOGNOSIE & BIOTECHNOL,F-63001 CLERMONT FERRAND,FRANCE
来源：
NUTRITION RESEARCH | 1996年 / 16卷 / 03期
关键词：
4-oxo-flavonoids; quercetin; antioxidant; cardiovascular diseases; antitumoral effect; carcinogenicity;
D O I：
10.1016/0271-5317(96)00032-2
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
4-oxo-flavonoids are dietary compounds widely distributed in the plant kingdom. Interest in these substances has arisen because of possible effects on human health. Indeed, in spite of extensive metabolism by the intestinal flora, 4-oxo-flavonoids seem to be sufficiently absorbed to have physiological effects. This review discusses the possibilities of a positive role in cardiovascular disease and cancer prevention, particularly by their antioxidant properties and their ability to modulate the activity of many enzymes, and summarizes the data concerning an eventual carcinogenicity of 4-oxo-flavonoids.
引用
收藏
页码：517 / 544
页数：28
相关论文
共 180 条
  • [1] CHELATING AND FREE-RADICAL SCAVENGING MECHANISMS OF INHIBITORY-ACTION OF RUTIN AND QUERCETIN IN LIPID-PEROXIDATION
    AFANASEV, IB
    DOROZHKO, AI
    BRODSKII, AV
    KOSTYUK, VA
    POTAPOVITCH, AI
    [J]. BIOCHEMICAL PHARMACOLOGY, 1989, 38 (11) : 1763 - 1769
  • [2] QUERCETIN EXERTS A PREFERENTIAL CYTOTOXIC EFFECT ON ACTIVE DIVIDING COLON-CARCINOMA HT29 AND CACO-2 CELLS
    AGULLO, G
    GAMET, L
    BESSON, C
    DEMIGNE, C
    REMESY, C
    [J]. CANCER LETTERS, 1994, 87 (01) : 55 - 63
  • [3] AKIYAMA T, 1987, J BIOL CHEM, V262, P5592
  • [4] SITE-SPECIFIC DNA CLEAVAGE BY MAMMALIAN DNA TOPOISOMERASE-II INDUCED BY NOVEL FLAVONE AND CATECHIN DERIVATIVES
    AUSTIN, CA
    PATEL, S
    ONO, K
    NAKANE, H
    FISHER, LM
    [J]. BIOCHEMICAL JOURNAL, 1992, 282 : 883 - 889
  • [5] AVILA MA, 1994, CANCER RES, V54, P2424
  • [6] AVIRAM M, 1992, CURRENT OPINION LIPI, V3, P344
  • [7] BASARKAR PW, 1981, INDIAN J EXP BIOL, V19, P787
  • [8] INHIBITION OF LACTATE TRANSPORT AND GLYCOLYSIS IN EHRLICH ASCITES TUMOR-CELLS BY BIOFLAVONOIDS
    BELT, JA
    THOMAS, JA
    BUCHSBAUM, RN
    RACKER, E
    [J]. BIOCHEMISTRY, 1979, 18 (16) : 3506 - 3511
  • [9] BERETZ A, 1986, PLANT FLAVONOIDS BIO, P281
  • [10] BERETZ A, 1981, BIOCHEM PHARMACOL, V31, P3597
12345678910