Multi-Functional Liposome: A Powerful Theranostic Nano-Platform Enhancing Photodynamic Therapy

被引：149

作者：

Cheng, Xiamin ^{[1
]}

Gao, Jing ^{[1
]}

Ding, Yang ^{[2
,3
]}

Lu, Yao ^{[2
,3
]}

Wei, Qiancheng ^{[1
]}

Cui, Dezhi ^{[1
]}

Fan, Jiali ^{[1
]}

Li, Xiaoman ^{[1
]}

Zhu, Ershu ^{[1
]}

Lu, Yongna ^{[1
]}

Wu, Qiong ^{[2
,3
]}

Li, Lin ^{[2
,3
]}

Huang, Wei ^{[2
,3
]}

机构：

[1] Nanjing Tech Univ NanjingTech, Sch Chem & Mol Engn, Inst Adv Synth, Nanjing 211816, Peoples R China

[2] Nanjing Tech Univ NanjingTech, Key Lab Flexible Elect KLOFE, Nanjing 211816, Peoples R China

[3] Nanjing Tech Univ NanjingTech, Inst Adv Mat IAM, Nanjing 211816, Peoples R China

来源：

ADVANCED SCIENCE | 2021年 / 8卷 / 16期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

combined therapy; drug delivery; liposomes; photodynamic therapy; theranostics; FORMULATED INDOCYANINE GREEN; DRUG-DELIVERY; TUMOR MICROENVIRONMENT; ZINC-PHTHALOCYANINE; CANCER-THERAPY; PHOTOSENSITIZING PROPERTIES; SENSITIVE LIPOSOMES; ANTICANCER POTENCY; TREATMENT EFFICACY; PROTOPORPHYRIN IX;

D O I：

10.1002/advs.202100876

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Although photodynamic therapy (PDT) has promising advantages in almost non-invasion, low drug resistance, and low dark toxicity, it still suffers from limitations in the lipophilic nature of most photosensitizers (PSs), short half-life of PS in plasma, poor tissue penetration, and low tumor specificity. To overcome these limitations and enhance PDT, liposomes, as excellent multi-functional nano-carriers for drug delivery, have been extensively studied in multi-functional theranostics, including liposomal PS, targeted drug delivery, controllable drug release, image-guided therapy, and combined therapy. This review provides researchers with a useful reference in liposome-based drug delivery.

引用

页数：31

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