The Role of Azithromycin in Patients with Cystic Fibrosis

被引：38
作者：
Yousef, Abdullah A. [1 ,2 ,3 ]
Jaffe, Adam [2 ,3 ]
机构：
[1] King Faisal Univ, Dept Paediat, Dammam, Saudi Arabia
[2] Univ New S Wales, Sch Womens & Childrens Hlth, Sydney, NSW 2052, Australia
[3] Sydney Childrens Hosp, Dept Resp Med, Randwick, NSW 2031, Australia
来源：
PAEDIATRIC RESPIRATORY REVIEWS | 2010年 / 11卷 / 02期
关键词：
macrolides; cystic fibrosis; inflammation; azithromycin; BRONCHIAL EPITHELIAL-CELLS; 14-MEMBERED RING MACROLIDES; LONG-TERM AZITHROMYCIN; NECROSIS-FACTOR-ALPHA; PSEUDOMONAS-AERUGINOSA; DIFFUSE PANBRONCHIOLITIS; IN-VITRO; CYTOKINE PRODUCTION; CONTROLLED-TRIAL; ERYTHROMYCIN;
D O I：
10.1016/j.prrv.2009.12.003
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Interest in azithromycin in the management of patients with cystic fibrosis has grown over the last decade. Uniquely this drug has both antibacterial and immune modulating effects which appear to be the reason for its clinical benefit as proven in several well designed clinical studies. In this review we discuss the proposed mechanisms of action of azithromycin and review the evidence for its clinical effectiveness and safety in cystic fibrosis. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：108 / 114
页数：7
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