Eliminating Meningococcal Epidemics From the African Meningitis Belt: The Case for Advanced Prevention and Control Using Next-Generation Meningococcal Conjugate Vaccines

被引：24

作者：

Alderson, Mark R. ^{[1
]}

LaForce, F. Marc ^{[4
]}

Sobanjo-ter Meulen, Ajoke ^{[2
]}

Hwang, Angela ^{[3
]}

Preziosi, Marie-Pierre ^{[5
]}

Klugman, Keith P. ^{[2
]}

机构：

[1] PATH, Ctr Vaccine Innovat & Access, Seattle, WA 98121 USA

[2] Bill & Melinda Gates Fdn, Seattle, WA USA

[3] Angela Hwang Consulting, Albany, CA USA

[4] Serum Inst India Pvt Ltd, Tech Serv, Pune, Maharashtra, India

[5] WHO, Immunizat Vaccines & Biol, Geneva, Switzerland

来源：

JOURNAL OF INFECTIOUS DISEASES | 2019年 / 220卷

基金：

比尔及梅琳达.盖茨基金会;

关键词：

meningitis belt; multivalent meningococcal vaccines; epidemic prevention; SEROGROUP; IMPACT; VACCINATION; CARRIAGE;

D O I：

10.1093/infdis/jiz297

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The introduction and rollout of a meningococcal serogroup A conjugate vaccine, MenAfriVac, in the African meningitis belt has eliminated serogroup A meningococcal infections for >300 million Africans. However, serogroup C, W, and X meningococci continue to circulate and have been responsible for focal epidemics in meningitis belt countries. Affordable multivalent meningococcal conjugate vaccines are being developed to prevent these non-A epidemics. This article describes the current epidemiologic situation and status of vaccine development and highlights questions to be addressed to most efficiently use these new vaccines.

引用

页码：S274 / S278

页数：5

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