The Past, Present, and Future of PrEP implementation Among People Who Use Drugs

被引：40

作者：

Biello, Katie B. ^{[1
,2
,3
,4
]}

Mimiaga, Matthew J. ^{[4
,5
,6
,7
]}

Valente, Pablo K. ^{[1
,3
]}

Saxena, Nimish ^{[4
]}

Bazzi, Angela R. ^{[8
,9
]}

机构：

[1] Brown Univ, Sch Publ Hlth, Dept Behav & Social Sci, Providence, RI 02912 USA

[2] Brown Univ, Dept Epidemiol, Dept Behav & Social Sci, Providence, RI 02912 USA

[3] Brown Univ, Ctr Hlth Promot & Hlth Equity, Providence, RI 02912 USA

[4] Fenway Hlth, Fenway Inst, Boston, MA USA

[5] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA USA

[6] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA

[7] Univ Calif Los Angeles, Ctr LGBTQ Advocacy Res & Hlth, Los Angeles, CA USA

[8] Boston Univ, Sch Publ Hlth, Dept Community Hlth Sci, Boston, MA USA

[9] Univ Calif San Diego, Herbert Wertheim Sch Publ Hlth & Human Longev Sci, San Diego, CA 92103 USA

来源：

CURRENT HIV/AIDS REPORTS | 2021年 / 18卷 / 04期

基金：

美国国家卫生研究院;

关键词：

PrEP; HIV; Substance use; Stimulants; Opioids; Injection drug use; HIV PREEXPOSURE PROPHYLAXIS; HEPATITIS-C VIRUS; INJECT DRUGS; UNITED-STATES; SUBSTANCE USE; SEXUAL RISK; ANTIRETROVIRAL PROPHYLAXIS; BEHAVIORAL ACTIVATION; OVERDOSE DEATHS; OPIOID USE;

D O I：

10.1007/s11904-021-00556-z

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Purpose of review Recent HIV outbreaks among people who use drugs (PWUD) necessitate additional HIV prevention tools. Pre-exposure prophylaxis (PrEP) is highly efficacious yet uptake among PWUD remains exceedingly low. To address multilevel, complex barriers to PrEP use among PWUD, a range of intervention strategies are needed. Recent findings The literature on interventions to optimize PrEP use among PWUD is nascent, comprising small pilots and demonstration projects in early phases of intervention development. Initial studies suggest that structural, healthcare, interpersonal, and individual-level interventions can improve PrEP use for PWUD, and a number of efficacy trials are underway. Future studies are needed to optimize the use of new PrEP modalities (e.g., injectable PrEP), simultaneously target multilevel challenges to PrEP use, and evaluate the integration of PrEP into other service settings and substance use treatment modalities.

引用

页码：328 / 338

页数：11

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