Three-component, four-centered, one-pot synthesis of 1-(arylethynyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole derivatives

被引：2

作者：

Reddy, B. V. Subba ^{[1
]}

Kota, Kavya ^{[1
,2
]}

Babu, R. Anji ^{[1
]}

Khan, P. Rasvan ^{[1
]}

Mukkanti, K. ^{[2
]}

机构：

[1] CSIR Indian Inst Chem Technol, Ctr Semiochem, Hyderabad 500007, Andhra Pradesh, India

[2] JNTU, Dept Chem, Hyderabad 500085, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2017年 / 58卷 / 22期

关键词：

Three component reaction; Halocyclization; Cyclic iminium ion; Alkyne addition; Tetrahydrocarbolines; TETRAHYDRO-BETA-CARBOLINES; PICTET-SPENGLER REACTION; ASYMMETRIC-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; MULTICOMPONENT REACTIONS; ALKALOIDS; TETRAHYDROISOQUINOLINES; CYCLIZATION; STRATEGIES; CHEMISTRY;

D O I：

10.1016/j.tetlet.2017.04.008

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient three component, four-centered A3 coupling strategy has been developed for the synthesis of a novel series of 1-arylethynyl-tetrahydro-beta-carboline derivatives in good yields with high selectivity. This method is also useful for the preparation of 1-arylethynyl tetrahydroisoquinolines, which can be used for the synthesis of biologically active molecules such as homolaudanosine, dysoxyline, methopo-line and almorexant. The use of a readily available ZnCl2/Et3N reagent system makes this method simple, convenient and practical. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：2088 / 2093

页数：6

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