Patterned Multiplex Pathogen DNA Detection by Au Particle-on-Wire SERS Sensor

被引：333

作者：

Kang, Taejoon ^{[1
]}

Yoo, Seung Min ^{[2
]}

Yoon, Ilsun ^{[1
]}

Lee, Sang Yup ^{[2
]}

Kim, Bongsoo ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Chem, Taejon 305701, South Korea

[2] Korea Adv Inst Sci & Technol, Dept Chem & Biomol Engn, Program BK21, Taejon 305701, South Korea

来源：

NANO LETTERS | 2010年 / 10卷 / 04期

关键词：

DNA; multiplex; pathogen; pattern; surface-enhanced Raman scattering; ENHANCED RAMAN-SCATTERING; REMOTE-EXCITATION; SILVER NANOWIRE; SINGLE-NANOWIRE; HOT-SPOTS; SPECTROSCOPY; NANOPARTICLES; HYBRIDIZATION; MOLECULES; SURFACES;

D O I：

10.1021/nl1000086

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Au particle-on-wire system that can be used as a specific, sensitive, and multiplex DNA sensor is developed. A pattern formed by multiple Au nanowire sensors provides positional address and identification for each sensor. By using this system, multiplex sensing of target DNAs was possible in a quantitative manner with a detection limit of 10 pM. Target DNAs from reference bacteria and clinical isolates were successfully identified by this sensor system, enabling diagnostics for infectious diseases.

引用

页码：1189 / 1193

页数：5

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