Modeling fractal-like drug elimination kinetics using an interacting random-walk model

被引:2
作者
Marsh, Rebeccah E. [1 ]
Riauka, Terence A.
机构
[1] Univ Alberta, Dept Phys, Edmonton, AB T6G 2J1, Canada
[2] Univ Alberta, Dept Oncol Med Phys, Edmonton, AB T6G 1Z2, Canada
来源
PHYSICAL REVIEW E | 2007年 / 75卷 / 03期
关键词
D O I
10.1103/PhysRevE.75.031902
中图分类号
O35 [流体力学]; O53 [等离子体物理学];
学科分类号
070204 ; 080103 ; 080704 ;
摘要
We introduce an interacting random-walk model to describe the residence time of drug molecules undergoing a series of sojourn times in the body before being permanently eliminated under either homogeneous or heterogeneous conditions. We show that short-term correlations between drug molecules lead to Michaelis-Menten kinetics while long-term correlations lead to transient fractal-like kinetics. By combining both types of correlation, fractal-like Michaelis-Menten kinetics are achieved, and the simulations confirm previous analytical results.
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页数:7
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