Transposable elements and the epigenetic regulation of the genome

被引：1374
|
作者：
Slotkin, R. Keith [1 ]
Martienssen, Robert [1 ]
机构：
[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
来源：
NATURE REVIEWS GENETICS | 2007年 / 8卷 / 04期
关键词：
POSITION-EFFECT VARIEGATION; SMALL INTERFERING RNAS; DNA METHYLATION; DROSOPHILA-MELANOGASTER; FISSION YEAST; ANTISENSE PROMOTER; MOBILE ELEMENTS; GENE-EXPRESSION; HETEROCHROMATIN; RETROTRANSPOSONS;
D O I：
10.1038/nrg2072
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Overlapping epigenetic mechanisms have evolved in eukaryotic cells to silence the expression and mobility of transposable elements (TEs). Owing to their ability to recruit the silencing machinery, TEs have served as building blocks for epigenetic phenomena, both at the level of single genes and across larger chromosomal regions. Important progress has been made recently in understanding these silencing mechanisms. In addition, new insights have been gained into how this silencing has been co-opted to serve essential functions in 'host' cells, highlighting the importance of TEs in the epigenetic regulation of the genome.
引用
收藏
页码：272 / 285
页数：14
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