The expression and significance of HIF-1α and GLUT-3 in glioma

被引：72

作者：

Liu, Yang ^{[1
,4
]}

Li, Yun-ming ^{[2
]}

Tian, Rui-feng ^{[3
]}

Liu, Wei-ping ^{[1
]}

Fei, Zhou ^{[1
]}

Long, Qian-fa ^{[1
]}

Wang, Xiao-an ^{[1
]}

Zhang, Xiang ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian 710032, Peoples R China

[2] Fourth Mil Med Univ, Dept Hlth Stat, Xian 710032, Peoples R China

[3] Fourth Mil Med Univ, Dist Retired Cadres Entertainment Ctr, Xian 710032, Peoples R China

[4] Third Hosp Mianyang, Dept Neurosurg, Mianyang 621000, Sichuan, Peoples R China

来源：

BRAIN RESEARCH | 2009年 / 1304卷

关键词：

HIF-1; alpha; GLUT-3; Glioma; Immunohistochemistry; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; GLUCOSE-TRANSPORT; FACTOR; 1-ALPHA; PROGRESSION; CANCER; ANGIOGENESIS; DEGRADATION; PROGNOSIS; MIGRATION; PREDICTS;

D O I：

10.1016/j.brainres.2009.09.083

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

HIF-1 alpha plays an indispensable role in tumor formation and histogenesis. Target genes involved in glucose transport are acutely transactivated by HIF-1 alpha. GLUT-3 protein is the rate-limiting factor related to glucose transport, which is classified as brain-type glucose transporter. This study was the initial one aiming to probe into the co-expression and clinical significance of HIF-1 alpha and GLUT-3 in glioma. One hundred and twenty cases of glioma tissues and ten human normal cerebral tissues decompressed in glioma excision were examined using immunohistochemistry and Western blot. The expression of HIF-1 alpha and GLUT-3 increased gradually with the increase of pathological grade of glioma, respectively. There was significant difference in the expression of HIF-1 alpha and GLUT-3 in every two groups, respectively. There was a positive correlation between HIF-1 alpha and GLUT-3. in conclusion, the expression of HIF-1 alpha and GLUT-3 in glioma was correlated significantly with tumors' pathological grade, which can be taken as a pair of useful markers for predicting the biological behavior of glioma. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：149 / 154

页数：6

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