Perioperative use of modified thrombelastography in factor XI deficiency:: a helpful method to assess drug effects

被引：21

作者：

Dirkmann, D. ^{[1
]}

Hanke, A. A. ^{[1
]}

Goerlinger, K. ^{[1
]}

Peters, J. ^{[1
]}

机构：

[1] Univ Klinikum Essen, Klin Anasthesiol & Intensivmed, Univ Duisberg Essen, D-45122 Essen, Germany

来源：

ACTA ANAESTHESIOLOGICA SCANDINAVICA | 2007年 / 51卷 / 05期

关键词：

thrombelastography; factor XI deficiency; fibrinolysis; recombinant factor VIIa; antifibrinolytics; tranexamic acid;

D O I：

10.1111/j.1399-6576.2007.01284.x

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Factor XI deficiency is a rare, hereditary bleeding disorder associated with a trauma-related bleeding tendency, caused by insufficient generation of the thrombin activatable fibrinolysis inhibitor (TAFI) evoking increased fibrinolysis. We present the case of a five year old girl with homozygote, severe factor XI deficiency presenting for surgery on two occasions. Modified thrombelastography (ROTEM (TM)) was used to assess effects of factor XI deficiency on coagulation, endogenous fibrinolysis, and potential effects of tranexamic acid, aprotinin and recombinant, activated Factor VII in an in vitro model of hyperfibrinolysis. According to our data and in consideration of the mechanisms of factor XI deficiency we decided on prophylactic use of tranexamic acid.

引用

页码：640 / 643

页数：4

共 15 条

[1] FACTOR-XI DEFICIENCY IN ASHKENAZI JEWS IN ISRAEL [J].