Enzymatic Machinery of Ubiquitin and Ubiquitin-Like Modification Systems in Chondrocyte Homeostasis and Osteoarthritis

被引：12

作者：

Liu, Ye ^{[1
]}

Molchanov, Vladimir ^{[1
]}

Yang, Tao ^{[1
]}

机构：

[1] Van Andel Inst, Dept Cell Biol, 333 Bostwick Ave NE, Grand Rapids, MI 49503 USA

来源：

CURRENT RHEUMATOLOGY REPORTS | 2021年 / 23卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

Post-translational modification; Ubl; SUMOylation; ATGylation; UFMylation; Cartilage; CELL-DEATH; TARGETED DELETION; GENOME-WIDE; AUTOPHAGY; SOX9; EXPRESSION; APOPTOSIS; CARTILAGE; DISEASE; INFLAMMATION;

D O I：

10.1007/s11926-021-01022-w

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of Review To date, a vast amount of information regarding ubiquitination (Ub) and ubiquitylation-like (Ubl) modification-related mechanisms has been reported in the context of skeletal cell homeostasis and diseases. In this review, we mainly focus on recent findings regarding the contribution of enzymatic machinery that directly adds or removes Ub and Ubl modifications from protein targets in chondrocyte homeostasis and osteoarthritis (OA) development. Recent Findings Mechanisms that promote homeostasis of articular chondrocytes are crucial for maintaining the integrity of articular joints to prevent osteoarthritis development. Articular chondrocytes are postmitotic cells that continuously produce and remodel cartilage matrix. In addition, the long lifespan of chondrocytes makes them susceptible to accumulating cellular damage. Ub and the evolutionarily conserved Ubl modifications, such as SUMOylation, ATGylation, and UFMylation, play important roles in promoting chondrocyte homeostasis, including regulating cell signaling and protein stability, resolving cellular stresses and inflammation, and maintaining differentiation and survival of chondrocytes. Uncovering new components/functions of Ub/Ubl modification machinery may provide novel drug targets to treat OA.

引用

页数：9

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