Colchicine Myopathy and Neuromyopathy Two Cases With Different Characteristics

被引：19

作者：

Cantarini, Luca ^{[1
]}

Volpi, Nila ^{[2
]}

Galeazzi, Mauro

Giani, Teresa ^{[3
,4
]}

Fanti, Francesca ^{[3
,4
]}

Lucherini, Orso Maria ^{[5
]}

Agliano, Margherita ^{[2
]}

Alessandrini, Carlo ^{[2
]}

Giannini, Fabio ^{[6
]}

Magi, Stefania ^{[7
]}

Greco, Giuseppe ^{[6
]}

Baldari, Cosima Tatiana ^{[5
]}

Cimaz, Rolando ^{[3
,4
]}

机构：

[1] Univ Siena, Policlin Le Scotte, Inst Rheumatol,Unit Rheumatol, Interdept Res Ctr Syst Autoimmune & Autoinflammat, I-53100 Siena, Italy

[2] Univ Siena, Dept Biomed Sci, Sect Anat & Histol, I-53100 Siena, Italy

[3] Anna Meyer Childrens Hosp, Dept Paediat, Rheumatol Unit, Florence, Italy

[4] Univ Florence, Florence, Italy

[5] Univ Siena, Dept Evolut Biol, I-53100 Siena, Italy

[6] Univ Siena, Policlin Le Scotte, Dept Neurosci, Neurol Sect, I-53100 Siena, Italy

[7] San Domenico Hosp ASL 7, Neurol Unit, Arezzo, Italy

来源：

JCR-JOURNAL OF CLINICAL RHEUMATOLOGY | 2010年 / 16卷 / 05期

关键词：

colchicine; FAMILIAL MEDITERRANEAN FEVER; NEUROPATHY; PATIENT; MUSCLE; INVOLVEMENT; APOPTOSIS;

D O I：

10.1097/RHU.0b013e3181e96342

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Colchicine, a long established anti-inflammatory agent now used in several rheumatologic conditions, acts by inhibiting microtubular polymerization, as it binds equimolarly to tubulin molecules. Cytoskeletal microtubules are crucial in processes of cell viability, such as mitosis and intracellular vesicle motility. Gastrointestinal side effects are quite common and often minor in nature or duration, whereas neuromuscular toxicity is rare. We report 2 cases of colchicine myopathy in the context of very different clinical settings.

引用

页码：229 / 232

页数：4

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