The effect of compound nutrients on stress-induced changes in serum IL-2, IL-6 and TNF-α levels in rats

被引：25

作者：

Liu Ya-Li

Bi Hui

Chi Su-Min

Fan Rong

Wang Yue-Min

Ma Xin-Liang

Chen Yao-Ming

Luo Wen-Jing

Pei Jian-Ming

Chen Jing-Yuan ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Dept Physiol, Xian 710032, Shaanxi, Peoples R China

[2] Fourth Mil Med Univ, Dept Environm & Occupat Hlth, Fac Mil Prevent Med, Xian 710032, Shaanxi, Peoples R China

来源：

CYTOKINE | 2007年 / 37卷 / 01期

基金：

中国国家自然科学基金;

关键词：

compound nutrients; cytokines; immobilization and cold water-immersion induced stress;

D O I：

10.1016/j.cyto.2007.02.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of compound nutrients on serum concentrations of the cytokines, such as interleukin (IL)-2, tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in immobilization and cold water-immersion stressed rat were investigated. Oral (gavage) administration of compound nutrients was found to attenuate the acute and chronic immobilization and cold water-immersion stress-induced increase in serum IL-6 level and decrease in IL-2 level. Compound nutrients exerted different effects on TNF-alpha level in two different models studied, with reduced serum TNF-alpha level in acute stress, while no significant effect in chronic stress. These results suggested that compound nutrients might be proposed as a possible candidate in the research or therapeutic modulation of stress-related disorders. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：14 / 21

页数：8

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