The effect of compound nutrients on stress-induced changes in serum IL-2, IL-6 and TNF-α levels in rats

被引：25
作者：
Liu Ya-Li
Bi Hui
Chi Su-Min
Fan Rong
Wang Yue-Min
Ma Xin-Liang
Chen Yao-Ming
Luo Wen-Jing
Pei Jian-Ming
Chen Jing-Yuan [1 ]
机构：
[1] Fourth Mil Med Univ, Dept Physiol, Xian 710032, Shaanxi, Peoples R China
[2] Fourth Mil Med Univ, Dept Environm & Occupat Hlth, Fac Mil Prevent Med, Xian 710032, Shaanxi, Peoples R China
来源：
CYTOKINE | 2007年 / 37卷 / 01期
基金：
中国国家自然科学基金;
关键词：
compound nutrients; cytokines; immobilization and cold water-immersion induced stress;
D O I：
10.1016/j.cyto.2007.02.009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of compound nutrients on serum concentrations of the cytokines, such as interleukin (IL)-2, tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in immobilization and cold water-immersion stressed rat were investigated. Oral (gavage) administration of compound nutrients was found to attenuate the acute and chronic immobilization and cold water-immersion stress-induced increase in serum IL-6 level and decrease in IL-2 level. Compound nutrients exerted different effects on TNF-alpha level in two different models studied, with reduced serum TNF-alpha level in acute stress, while no significant effect in chronic stress. These results suggested that compound nutrients might be proposed as a possible candidate in the research or therapeutic modulation of stress-related disorders. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：14 / 21
页数：8
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