Is Halogen Bonding the Basis for Iodothyronine Deiodinase Activity?

被引：64
作者：
Bayse, Craig A. [1 ]
Rafferty, Erin R. [1 ]
机构：
[1] Old Dominion Univ, Dept Chem & Biochem, Norfolk, VA 23529 USA
来源：
INORGANIC CHEMISTRY | 2010年 / 49卷 / 12期
关键词：
SELENIUM; RECOGNITION; ORIGIN;
D O I：
10.1021/ic100711n
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Density functional theory studies of S center dot center dot center dot X and Se center dot center dot center dot X (X = Br, I) halogen-bonding interactions are used to interpret the selection of selenium and iodine for thyroid hormone signaling. A new mechanism for dehalogenation in terms of halogen bonding is proposed. The, activation barriers for deiodination of an aromatic iodide by MeSeH and MeSH (17.6 and 19.8 kcal/mol) are consistent with the relative rates, of deiodination by iodothyronine deiodinase and its cysteine mutant.
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收藏
页码：5365 / 5367
页数：3
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