Visible Light-Mediated Polymerization-Induced Self-Assembly Using Continuous Flow Reactors

被引：108
作者：
Zaquen, Neomy [1 ,2 ,3 ]
Yeow, Jonathan [1 ,2 ]
Junkers, Tanja [3 ,4 ]
Boyer, Cyrille [1 ,2 ]
Zetterlund, Per B. [1 ]
机构：
[1] Univ New South Wales, CAMD, High St Gate 2, Sydney, NSW 2033, Australia
[2] Univ New South Wales, Australian Ctr Nanomed, High St Gate 2, Sydney, NSW 2033, Australia
[3] Univ Hasselt, Organ & Biopolymer Chem OBPC, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium
[4] Monash Univ, Sch Chem, Polymer React Design Grp, 19 Rainforest Walk, Melbourne, Vic 3800, Australia
来源：
MACROMOLECULES | 2018年 / 51卷 / 14期
关键词：
RAFT DISPERSION POLYMERIZATION; COPOLYMER NANO-OBJECTS; BLOCK-COPOLYMER; RADICAL POLYMERIZATION; PHOTO-PISA; NANOPARTICLES; MORPHOLOGY; VESICLES; ROUTE; PHOTOPOLYMERIZATION;
D O I：
10.1021/acs.macromol.8b00887
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
We present the synthesis of polymeric nano-particles of targeted morphology in a continuous process via visible light-mediated aqueous RAFT polymerization-induced self-assembly (PISA). A trithiocarbonate-derived poly-(ethylene glycol) (PEG) macroRAFT was activated in the presence of hydroxypropyl methacrylate (HPMA) at 37 degrees C under blue light irradiation (460 nm), leading to the formation of PEG-b-P(HPMA) nanoparticles. The method is attractive in its simplicity-spheres, worms, and vesicles can easily be obtained in a continuous fashion with higher control in comparison to conventional batch procedures. This allows for more accurate production of particle morphologies and scalable synthesis of these nano-objects. The versatility of this process was demonstrated by the in situ encapsulation of an active compound.
引用
收藏
页码：5165 / 5172
页数：8
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