Visible Light-Mediated Polymerization-Induced Self-Assembly Using Continuous Flow Reactors

被引：110

作者：

Zaquen, Neomy ^{[1
,2
,3
]}

Yeow, Jonathan ^{[1
,2
]}

Junkers, Tanja ^{[3
,4
]}

Boyer, Cyrille ^{[1
,2
]}

Zetterlund, Per B. ^{[1
]}

机构：

[1] Univ New South Wales, CAMD, High St Gate 2, Sydney, NSW 2033, Australia

[2] Univ New South Wales, Australian Ctr Nanomed, High St Gate 2, Sydney, NSW 2033, Australia

[3] Univ Hasselt, Organ & Biopolymer Chem OBPC, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium

[4] Monash Univ, Sch Chem, Polymer React Design Grp, 19 Rainforest Walk, Melbourne, Vic 3800, Australia

来源：

MACROMOLECULES | 2018年 / 51卷 / 14期

关键词：

RAFT DISPERSION POLYMERIZATION; COPOLYMER NANO-OBJECTS; BLOCK-COPOLYMER; RADICAL POLYMERIZATION; PHOTO-PISA; NANOPARTICLES; MORPHOLOGY; VESICLES; ROUTE; PHOTOPOLYMERIZATION;

D O I：

10.1021/acs.macromol.8b00887

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

We present the synthesis of polymeric nano-particles of targeted morphology in a continuous process via visible light-mediated aqueous RAFT polymerization-induced self-assembly (PISA). A trithiocarbonate-derived poly-(ethylene glycol) (PEG) macroRAFT was activated in the presence of hydroxypropyl methacrylate (HPMA) at 37 degrees C under blue light irradiation (460 nm), leading to the formation of PEG-b-P(HPMA) nanoparticles. The method is attractive in its simplicity-spheres, worms, and vesicles can easily be obtained in a continuous fashion with higher control in comparison to conventional batch procedures. This allows for more accurate production of particle morphologies and scalable synthesis of these nano-objects. The versatility of this process was demonstrated by the in situ encapsulation of an active compound.

引用

页码：5165 / 5172

页数：8

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