Visible Light-Mediated Polymerization-Induced Self-Assembly Using Continuous Flow Reactors

被引：109

作者：

Zaquen, Neomy ^{[1
,2
,3
]}

Yeow, Jonathan ^{[1
,2
]}

Junkers, Tanja ^{[3
,4
]}

Boyer, Cyrille ^{[1
,2
]}

Zetterlund, Per B. ^{[1
]}

机构：

[1] Univ New South Wales, CAMD, High St Gate 2, Sydney, NSW 2033, Australia

[2] Univ New South Wales, Australian Ctr Nanomed, High St Gate 2, Sydney, NSW 2033, Australia

[3] Univ Hasselt, Organ & Biopolymer Chem OBPC, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium

[4] Monash Univ, Sch Chem, Polymer React Design Grp, 19 Rainforest Walk, Melbourne, Vic 3800, Australia

来源：

MACROMOLECULES | 2018年 / 51卷 / 14期

关键词：

RAFT DISPERSION POLYMERIZATION; COPOLYMER NANO-OBJECTS; BLOCK-COPOLYMER; RADICAL POLYMERIZATION; PHOTO-PISA; NANOPARTICLES; MORPHOLOGY; VESICLES; ROUTE; PHOTOPOLYMERIZATION;

D O I：

10.1021/acs.macromol.8b00887

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

We present the synthesis of polymeric nano-particles of targeted morphology in a continuous process via visible light-mediated aqueous RAFT polymerization-induced self-assembly (PISA). A trithiocarbonate-derived poly-(ethylene glycol) (PEG) macroRAFT was activated in the presence of hydroxypropyl methacrylate (HPMA) at 37 degrees C under blue light irradiation (460 nm), leading to the formation of PEG-b-P(HPMA) nanoparticles. The method is attractive in its simplicity-spheres, worms, and vesicles can easily be obtained in a continuous fashion with higher control in comparison to conventional batch procedures. This allows for more accurate production of particle morphologies and scalable synthesis of these nano-objects. The versatility of this process was demonstrated by the in situ encapsulation of an active compound.

引用

页码：5165 / 5172

页数：8

共 65 条

[1] Challenges and Opportunities in Continuous Production of Emulsion Polymers: a Review [J].

Asua, Jose M. .

MACROMOLECULAR REACTION ENGINEERING, 2016, 10 (04) :311-323

[2] Permeable Protein-Loaded Polymersome Cascade Nanoreactors by Polymerization-Induced Self-Assembly [J].

Blackman, Lewis D. ;

Varlas, Spyridon ;

Arno, Maria C. ;

Fayter, Alice ;

Gibson, Matthew I. ;

O'Reilly, Rachel K. .

ACS MACRO LETTERS, 2017, 6 (11) :1263-1267

[3]

Blackman LD, 2017, POLYM CHEM-UK, V8, P2860, DOI [10.1039/C7PY00407A, 10.1039/c7py00407a]

[4] Mechanistic Insights for Block Copolymer Morphologies: How Do Worms Form Vesicles? [J].

Blanazs, Adam ;

Madsen, Jeppe ;

Battaglia, Giuseppe ;

Ryan, Anthony J. ;

Armes, Steven P. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (41) :16581-16587

[5] Multi-step continuous-flow synthesis [J].

Britton, Joshua ;

Raston, Colin L. .

CHEMICAL SOCIETY REVIEWS, 2017, 46 (05) :1250-1271

[6] Applications of Continuous-Flow Photochemistry in Organic Synthesis, Material Science, and Water Treatment [J].

Cambie, Dario ;

Bottecchia, Cecilia ;

Straathof, Natan J. W. ;

Hessel, Volker ;

Noel, Timothy .

CHEMICAL REVIEWS, 2016, 116 (17) :10276-10341

[7] A Critical Appraisal of RAFT-Mediated Polymerization-Induced Self Assembly [J].

Canning, Sarah L. ;

Smith, Gregory N. ;

Armes, Steven P. .

MACROMOLECULES, 2016, 49 (06) :1985-2001

[8] Polymerization-Induced Self-Assembly: From Soluble Macromolecules to Block Copolymer Nano-Objects in One Step [J].

Charleux, Bernadette ;

Delaittre, Guillaume ;

Rieger, Jutta ;

D'Agosto, Franck .

MACROMOLECULES, 2012, 45 (17) :6753-6765

[9] Flash Latex Production in a Continuous Helical Photoreactor: Releasing the Brake Pedal on Acrylate Chain Radical Polymerization [J].

Chemtob, Abraham ;

Lobry, Emeline ;

Rannee, Agnes ;

Jasinski, Florent ;

Penconi, Marta ;

Oliveros, Esther ;

Braun, Andre M. ;

Criqui, Adrien .

MACROMOLECULAR REACTION ENGINEERING, 2016, 10 (03) :261-268

[10] Light-Controlled Radical Polymerization: Mechanisms, Methods, and Applications [J].

Chen, Mao ;

Zhong, Mingjiang ;

Johnson, Jeremiah A. .

CHEMICAL REVIEWS, 2016, 116 (17) :10167-10211

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