Reading the prognosis of the individual with breast cancer

被引：39

作者：

Blamey, R. W. ^{[1
]}

Pinder, S. E. ^{[1
]}

Ball, G. R. ^{[1
]}

Ellis, I. O. ^{[1
]}

Elston, C. W. ^{[1
]}

Mitchell, M. J. ^{[1
]}

Haybittle, J. L. ^{[1
]}

机构：

[1] City Hosp Nottingham, Breast Inst, Nottingham NG5 1PB, England

来源：

EUROPEAN JOURNAL OF CANCER | 2007年 / 43卷 / 10期

关键词：

breast cancer; prognosis; prognosis of individual; case survival; improved prognostic discrimination;

D O I：

10.1016/j.ejca.2007.01.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: To obtain better survival estimates for the individual than is provided by placement in an NPI group. Method: Consecutive primary operable breast cancers treated at Nottingham City Hospital 1990-1999. Ten year % actuarial survivals plotted for 10 ranges of NPI from 2.0 to 6.9. There is an excellent inverse correlation between median NPI value for each range and survival at 10 years. To enable estimation of survival for all individual values of NPI, a curve fitting technique applied to these results (by G.B.) gave the formula to estimate survival from the individual's NPI score: 10 year % survival for the individual = -3.0079 x NpI2 + 12.30 x NPI + 83.84. This gave an r(2) of 0.98. Results and conclusion: Greater accuracy in individual survival prediction is obtained by dividing women into 10 groups by NPI scores than in the originally described six groups; rank order of survival in relation to NPI score is preserved. A curve fitting technique has been applied to these data to give a formula for the prediction of 10 year survival for every 0.1 value of NPI. (C) 2007 Published by Elsevier Ltd.

引用

页码：1545 / 1547

页数：3

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