Heterocycles 26: synthesis, characterisation, and anticancer activity of some thiazolic chalcones

被引：17

作者：

Awoussong, Patrice K. ^{[1
,2
]}

Zaharia, Valentin ^{[2
]}

Ngameni, Bathelemy ^{[3
]}

Kuete, Victor ^{[4
]}

Ntede, Hippolyte N. ^{[5
]}

Fokunang, Charles N. ^{[3
]}

Abegaz, Berhanu M. ^{[6
]}

Ngadjui, Bonaventure T. ^{[1
,3
]}

机构：

[1] Univ Yaounde I, Fac Sci, Yaounde, Cameroon

[2] Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Cluj Napoca 400012, Romania

[3] Univ Yaounde I, Fac Med & Biomed Sci, Yaounde, Cameroon

[4] Univ Dschang, Fac Sci, Dschang, Cameroon

[5] Univ Yaounde I, Natl Adv Sch Engn, Yaounde, Cameroon

[6] African Acad Sci, Nairobi, Kenya

来源：

MEDICINAL CHEMISTRY RESEARCH | 2015年 / 24卷 / 01期

关键词：

Thiazolic chalcones; Prostate cancer; Hepatocarcinoma; Human monocytic leukemia; CANCER;

D O I：

10.1007/s00044-014-1096-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chalcones and their derivatives have been shown to have potent anticancer activity. A series of aldehydes A (1-4) and thiazolic chalcones C (1-20) were synthesized and evaluated for their in vitro cytotoxic activity against three human cancer cell lines. In addition, this work led to the synthesis of 12 new thiazolic chalcones using a base-catalyzed Claisen-Schmidt condensation reaction. Compounds C (10) and C (12) were found to be the most promising biologically active samples with IC50 values below or around 10 A mu M on both DU-145 and THP-1 cancer cell lines.

引用

页码：131 / 141

页数：11

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