Synapsin IIb interacts with the C-terminal SH2 and SH3 domains of PLCγ1 and inhibits its enzymatic activity

被引：2

作者：

Han, SJ

Hong, SH

Kim, CG ^{[1
]}

Lee, JB

Choi, DK

Kim, KR

Kim, CG ^{[1
]}

机构：

[1] Konkuk Univ, Dept Biotechnol, Chungju, South Korea

[2] Seoul Natl Univ, Sch Biol Sci, Seoul, South Korea

[3] Hanyang Univ, Dept Life Sci, Seoul 133791, South Korea

[4] Hanyang Univ, Res Inst Nat Sci, Seoul 133791, South Korea

[5] Konkuk Univ, Coll Med, Dept Surg, Chungju, South Korea

来源：

CELL BIOLOGY INTERNATIONAL | 2004年 / 28卷 / 12期

关键词：

PLC gamma 1; synapsin IIb; SH2; SH3; binding protein;

D O I：

10.1016/j.cellbi.2004.09.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

To elucidate the function of PLCgamma1, we have investigated the proteins that bind to its SH (Src homology) domain. Immunoscreening was performed with purified antisera specific for SH223 (two SH2 and one SH3)-binding proteins. Several immunoreactive clones were identified as putative binding proteins and one of them was identified as synapsin IIb. We demonstrate a stable association between PLCgammal and synapsin IIb, which binds the carboxyl terminal SH2 and SH3 domains of the enzyme and inhibits it. (C) 2004 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.

引用

页码：943 / 948

页数：6

共 29 条

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