Tobacco-specific N-nitrosamines NNN and NNK levels in cigarette brands between 2000 and 2014

被引：24

作者：

Gunduz, I. ^{[1
]}

Kondylis, A. ^{[1
]}

Jaccard, G. ^{[2
]}

Renaud, J. -M. ^{[1
]}

Hofer, R. ^{[1
]}

Ruffieux, L. ^{[3
]}

Gadani, F. ^{[1
]}

机构：

[1] Philip Morris Prod SA, Prod Dev, Rue Usines 56, CH-2000 Neuchatel, Switzerland

[2] Philip Morris Int Management SA, Prod & Proc Qual, Quai Jeanrenaud 56, CH-2000 Neuchatel, Switzerland

[3] Philip Morris Int Management SA, Leaf Agr Programs, Ave Rhodanie 50, CH-1001 Lausanne, Switzerland

来源：

REGULATORY TOXICOLOGY AND PHARMACOLOGY | 2016年 / 76卷

关键词：

TSNA; NNN; NNK; Tobacco; Cigarette smoke; Smoke transfer; NICOTIANA-TABACUM; MAINSTREAM SMOKE; FORMALDEHYDE; NORNICOTINE;

D O I：

10.1016/j.yrtph.2016.01.012

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

The evolution of the levels of tobacco-specific N-nitrosamines (TSNA), N-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in mainstream (MS) cigarette smoke is investigated based on smoke and tobacco chemistry data of cigarette brands sold by Philip Morris International (PMI) between 2000 and 2014. A total of 315 cigarette samples representing a wide range of product and design characteristics manufactured by PMI between 2008 and 2014 were analyzed and compared to a previously published dataset of PMI brands manufactured in 2000. The data indicate that there is a substantial reduction of NNN and NNK levels in tobacco fillers and MS cigarette smoke per mg of tar and per mg of nicotine using Health Canada Intense (HCI) machine-smoking regime. This observed reduction in NNN and NNK levels in MS cigarette smoke is also supported by the downward trend observed on NNN and NNK levels in USA flue-cured Virginia and Burley tobacco lots from 2000 to 2014 crops, reflecting effectiveness of measures taken on curing and agricultural practices designed to minimize TSNA formation in tobacco. (C) 2016 The Authors. Published by Elsevier Inc.

引用

页码：113 / 120

页数：8

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