Maternal lifestyle factors in pregnancy and congenital heart defects in offspring: review of the current evidence

被引：34

作者：

Feng, Yu ^{[1
]}

Yu, Di ^{[1
]}

Yang, Lei ^{[1
]}

Da, Min ^{[1
]}

Wang, Zhiqi ^{[1
]}

Lin, Yuan ^{[2
]}

Ni, Bixian ^{[2
]}

Wang, Song ^{[1
]}

Mo, Xuming ^{[1
]}

机构：

[1] Nanjing Med Univ, Dept Cardiothorac Surg, Affiliated Childrens Hosp, Nanjing, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Sch Publ Hlth, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Dept Epidemiol & Biostat,Canc Ctr, Nanjing, Jiangsu, Peoples R China

来源：

ITALIAN JOURNAL OF PEDIATRICS | 2014年 / 40卷

关键词：

Congenital heart defects; Maternal lifestyle factors; Smoking; BMI; BODY-MASS INDEX; BIRTH-DEFECTS; RISK-FACTORS; CARDIOVASCULAR-DISEASE; SCIENTIFIC STATEMENT; ALCOHOL-CONSUMPTION; CURRENT KNOWLEDGE; SMOKING; ASSOCIATION; POPULATION;

D O I：

10.1186/s13052-014-0085-3

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The prognosis of children with congenital heart defects(CHDs) continues to improve with advancing surgical techniques; however, lack of information about modifiable risk factors for malformations in cardiovascular development impeded the prevention of CHDs. We investigated an association between maternal lifestyle factors and the risk of CHDs, because epidemiological studies have reported conflicting results regarding maternal lifestyle factors and the risk of CHDs recently. A review published on 2007 provided a summary of maternal exposures associated with an increased risk of CHDs. As part of noninherited risk factors, we conducted a brief overview of studies on the evidence linking common maternal lifestyle factors, specifically smoking, alcohol, illicit drugs, caffeine, body mass index and psychological factors to the development of CHDs in offspring. Women who smoke and have an excessive body mass index(BMI) during pregnancy are suspected to be associated with CHDs in offspring. Our findings could cause public health policy makers to pay more attention to women at risk and could be used in the development of population-based prevention strategies to reduce the incidence and burden of CHDs. However, more prospective studies are needed to investigate the association between maternal lifestyle factors and CHDs.

引用

页数：7

共 55 条

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