The role of STAT3 in glioblastoma progression through dual influences on tumor cells and the immune microenvironment

被引：81

作者：

Chang, Nakho ^{[1
,2
]}

Ahn, Sun Hee ^{[1
,2
]}

Kong, Doo-Sik ^{[3
]}

Lee, Hye Won ^{[2
,4
]}

Nam, Do-Hyun ^{[1
,2
,3
]}

机构：

[1] Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol, Dept Hlth Sci & Technol, Seoul 06351, South Korea

[2] Samsung Med Ctr, Inst Refractory Canc Res, Seoul 06351, South Korea

[3] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurosurg, Seoul 06351, South Korea

[4] Samsung Med Ctr, Inst Future Med, Seoul 06351, South Korea

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2017年 / 451卷 / 0C期

基金：

新加坡国家研究基金会;

关键词：

Signal transducer and activator of transcription 3; Glioblastoma multiforme; Tumor progression; Tumor microenvironment; Prognosis; Therapeutic target; REGULATORY T-CELLS; EPIDERMAL-GROWTH-FACTOR; PRIMARY INTRACRANIAL TUMORS; NF-KAPPA-B; DNA-BINDING ACTIVITY; STEM-LIKE CELLS; SIGNALING INDUCES APOPTOSIS; COLONY-STIMULATING FACTOR; SMALL-MOLECULE INHIBITOR; PREDICTS POOR-PROGNOSIS;

D O I：

10.1016/j.mce.2017.01.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Glioblastoma multiforme (GBM) is the most aggressive form of cancer that begins within the brain; generally, the patient has a dismal prognosis and limited therapeutic options. Signal transducer and activator of transcription 3 (STAT3) is a critical mediator of tumorigenesis, tumor progression, and suppression of anti-tumor immunity in GBM. In a high percentage of GBM cells and tumor microenvironments, persistent activation of STAT3 induces cell proliferation, anti-apoptosis, glioma stem cell maintenance, tumor invasion, angiogenesis, and immune evasion. This makes STAT3 an attractive therapeutic target and a prognostic indicator in GBM. Targeting STAT3 affords an opportunity to disrupt multiple pro-oncogenic pathways at a single molecular hub. Unfortunately, there are no successful STAT3 inhibitors currently in clinical trials. However, strong clinical evidence implicating STAT3 as a major factor in GBM justifies the identification of safe and effective strategies for inhibiting STAT3. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：53 / 65

页数：13

共 260 条

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