Triggered and catalyzed self-assembly of hyperbranched DNA structures for logic operations and homogeneous CRET biosensing of microRNA

被引：64

作者：

Bi, Sai ^{[1
]}

Yue, Shuzhen ^{[1
]}

Wu, Qiang ^{[2
]}

Ye, Jiayan ^{[3
]}

机构：

[1] Qingdao Univ, Collaborat Innovat Ctr Marine Biomass Fiber Mat &, Coll Chem & Chem Engn,Lab Fiber Mat & Modern Text, Growing Base State Key Lab,Shandong Sinojapanese, Qingdao 266071, Peoples R China

[2] Chinese Acad Fishery Sci, Key Lab Sustainable Dev Marine Fisheries, Shandong Prov Key Lab Fishery Resources & Ecoenvi, Minist Agr,Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China

[3] Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Minist Educ, Key Lab Sensor Anal Tumor Marker, Qingdao 266042, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 31期

基金：

中国国家自然科学基金;

关键词：

HYBRIDIZATION CHAIN-REACTION; RESONANCE ENERGY-TRANSFER; STRAND-DISPLACEMENT CIRCUITRY; FUELED MOLECULAR MACHINE; NUCLEIC-ACIDS; CHEMILUMINESCENCE; COMPUTATION; NANOSTRUCTURES; NANOTECHNOLOGY; AMPLIFICATION;

D O I：

10.1039/c6cc01308b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Toehold-mediated strand displacement-based nanocircuits are developed by integrating catalytic hairpin assembly (CHA) with hybridization chain reaction (HCR), which achieves self-assembly of hyperbranched DNA structures and is readily utilized as an enzyme-free amplifier for homogeneous CRET detection of microRNA with high sensitivity and selectivity.

引用

页码：5455 / 5458

页数：4

共 37 条

[1] Hyperbranched Hybridization Chain Reaction for Triggered Signal Amplification and Concatenated Logic Circuits [J].

Bi, Sai ;

Chen, Min ;

Jia, Xiaoqiang ;

Dong, Ying ;

Wang, Zonghua .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015, 54 (28) :8144-8148

[2] A hot-spot-active magnetic graphene oxide substrate for microRNA detection based on cascaded chemiluminescence resonance energy transfer [J].

Bi, Sai ;

Chen, Min ;

Jia, Xiaoqiang ;

Dong, Ying .

NANOSCALE, 2015, 7 (08) :3745-3753

[3] A graphene oxide platform for the assay of biomolecules based on chemiluminescence resonance energy transfer [J].

Bi, Sai ;

Zhao, Tingting ;

Luo, Baoyu .

CHEMICAL COMMUNICATIONS, 2012, 48 (01) :106-108

[4] Stacking nonenzymatic circuits for high signal gain [J].

Chen, Xi ;

Briggs, Neima ;

McLain, Jeremy R. ;

Ellington, Andrew D. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (14) :5386-5391

[5] Expanding the Rule Set of DNA Circuitry with Associative Toehold Activation [J].

Chen, Xi .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 134 (01) :263-271

[6] Shaping up nucleic acid computation [J].

Chen, Xi ;

Ellington, Andrew D. .

CURRENT OPINION IN BIOTECHNOLOGY, 2010, 21 (04) :392-400

[7]

Chen YJ, 2015, NAT NANOTECHNOL, V10, P748, DOI [10.1038/nnano.2015.195, 10.1038/NNANO.2015.195]

[8] Molecular Fluorescence, Phosphorescence, and Chemiluminescence Spectrometry [J].

Das, Susmita ;

Powe, Aleeta M. ;

Baker, Gary A. ;

Valle, Bertha ;

El-Zahab, Bilal ;

Sintim, Herman O. ;

Lowry, Mark ;

Fakayode, Sayo O. ;

McCarroll, Matthew E. ;

Patonay, Gabor ;

Li, Min ;

Strongin, Robert M. ;

Geng, Maxwell L. ;

Warner, Isiah M. .

ANALYTICAL CHEMISTRY, 2012, 84 (02) :597-625

[9]

Diaz AN, 1997, J BIOLUM CHEMILUM, V12, P199, DOI 10.1002/(SICI)1099-1271(199707/08)12:4<199::AID-BIO445>3.0.CO

[10]

2-U

← 1 2 3 4 →