In vivo blood viscosity characterization based on frequency-resolved photoacoustic measurement

被引：12

作者：

Zhao, Yue ^{[1
]}

Yang, Shaozhuang ^{[1
]}

Wang, Yating ^{[2
]}

Yuan, Zhen ^{[2
]}

Qu, Junle ^{[1
]}

Liu, Liwei ^{[1
]}

机构：

[1] Shenzhen Univ, Coll Optoelect Engn, Minist Educ & Guangdong Prov, Key Lab Optoelect Devices & Syst, Shenzhen 518060, Peoples R China

[2] Univ Macau, Fac Hlth Sci, Bioimaging Core, Taipa 999078, Macau Sar, Peoples R China

来源：

APPLIED PHYSICS LETTERS | 2018年 / 113卷 / 14期

基金：

中国国家自然科学基金;

关键词：

HEAT-CONDUCTION; MICROSCOPY; MICROCIRCULATION; TOMOGRAPHY; OXYGEN; FLOW;

D O I：

10.1063/1.5039538

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

In this letter, we proposed a photoacoustic (PA) method for noninvasively detecting blood viscosity in subcutaneous microvasculature with the frequency-resolved measurement. The influence of viscosity on PA generation was investigated theoretically, and a negative correlation was shown between the viscosity and the full width at half maximum (FWHM) of the PA frequency spectrum, which can be utilized to reflect the viscosity distribution. To test the feasibility and accuracy of this method, water mixed with different concentrations of glycerol was measured. FWHM of the PA frequency spectrum was also obtained in vivo in the mouse ear to characterize the blood viscosity from different vessel bifurcations, and the metabolism-induced viscosity changes were dynamically monitored in the microvasculature. Experimental results demonstrate that this technique has future potential clinical applications for real-time monitoring the viscosity changes in subcutaneous microvasculature. Published by AIP Publishing.

引用

页数：5

共 23 条

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Baskurt OK, 2003, SEMIN THROMB HEMOST, V29, P435

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