Effect of sodium ferulate on the hyperalgesia mediated by P2X3 receptor in the neuropathic pain rats

被引：37

作者：

Zhang, Aixia ^{[1
]}

Gao, Yun ^{[1
]}

Zhong, Xiaoqin ^{[2
]}

Xu, Changshui ^{[1
]}

Li, Guilin ^{[1
]}

Liu, Shuangmei ^{[1
]}

Lin, Jiari ^{[1
]}

Li, Xin ^{[1
]}

Zhang, Yun ^{[1
]}

Liu, Han ^{[1
]}

Linag, Shangdong ^{[1
]}

机构：

[1] Nanchang Univ, Basic Med Coll, Dept Physiol, Nanchang 330006, Jiangxi, Peoples R China

[2] Nanchang Univ, Basic Med Coll, Dept Pathol, Nanchang 330006, Jiangxi, Peoples R China

来源：

BRAIN RESEARCH | 2010年 / 1313卷

基金：

中国国家自然科学基金;

关键词：

Neuropathic pain; P2X(3) receptor; Sodium ferulate; Dorsal root ganglion; PURINERGIC RECEPTORS; SENSORY NEURONS; P2; RECEPTORS; TETRAMETHYLPYRAZINE; TARGETS; ATP; ACTIVATION; MECHANISMS; INVOLVEMENT; NOCICEPTION;

D O I：

10.1016/j.brainres.2009.11.067

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuropathic pain is usually persistent and there is no effective treatment. Activation of P2X(3) receptor subtype in primary sensory neurons is involved in neuropathic pain. Sodium ferulate (SF) is an active principle from Chinese herbal medicine and has anti-inflammatory activities. This study observed the effects of SF on the hyperalgesia mediated by P2X(3) receptor of rats after chronic constriction injury (CCI). Mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) were measured and the expression of P2X(3) receptor immunoreactivity and protein in dorsal root ganglion (DRG) neurons was analyzed by immunohistochemistry and western blotting. In CCI rats treated with SF, the MWT and TWL were increased compared with CCI rats treated with normal saline. The expression of P2X(3) receptor in DRG neurons was increased after CCI. In CCI rats treated with SF, the upregulated expression of P2X(3) receptor in DRG neurons was reduced. SF may reduce the thermal and mechanical hyperalgesia in CCI rat model by decreasing the pain transmitted by primary afferant neurons mediated by P2X(3) receptor during the chronic neuropathic pain injury. (c) 2009 Elsevier B.V. All rights reserved.

引用

页码：215 / 221

页数：7

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