The impact of production of extended-spectrum β-lactamases on the 28-day mortality rate of patients with Proteus mirabilis bacteremia in Korea

被引：25

作者：

Ahn, Jin Young ^{[1
,2
]}

Ann, Hea Won ^{[2
,3
]}

Jeon, Yongduk ^{[2
,3
]}

Ahn, Mi Young ^{[2
,3
]}

Oh, Dong Hyun ^{[2
,3
]}

Kim, Yong Chan ^{[2
,3
]}

Kim, Eun Jin ^{[2
,3
]}

Song, Je Eun ^{[4
]}

Jung, In Young ^{[2
,3
]}

Kim, Moo Hyun ^{[2
]}

Jeong, Wooyoung ^{[2
]}

Ku, Nam Su ^{[2
,3
,6
,7
]}

Jeong, Su Jin ^{[2
,3
]}

Choi, Jun Yong ^{[2
,3
]}

Yong, Dongeun ^{[5
]}

Song, Young Goo ^{[2
,3
]}

Kim, June Myung ^{[2
,3
]}

机构：

[1] Seoul Med Ctr, Dept Internal Med, Seoul, South Korea

[2] Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea

[3] Yonsei Univ, Coll Med, AIDS Res Inst, Seoul, South Korea

[4] Inje Univ, Ilsan Paik Hosp, Coll Med, Dept Internal Med, Goyang, South Korea

[5] Yonsei Univ, Coll Med, Dept Lab Med, Seoul, South Korea

[6] Yonsei Univ, Coll Med, Dept Internal Med, 50-1 Yonsei Ro, Seoul 120752, South Korea

[7] Yonsei Univ, Coll Med, AIDS Res Inst, 50-1 Yonsei Ro, Seoul 120752, South Korea

来源：

BMC INFECTIOUS DISEASES | 2017年 / 17卷

关键词：

Proteus Mirabilis; Bacteremia; Extended-spectrum beta-lactamase; Mortality; BLOOD-STREAM INFECTIONS; URINARY-TRACT-INFECTIONS; ESCHERICHIA-COLI; KLEBSIELLA-PNEUMONIAE; RISK-FACTORS; CTX-M; ANTIMICROBIAL SUSCEPTIBILITY; PIPERACILLIN-TAZOBACTAM; CLINICAL-SIGNIFICANCE; NOSOCOMIAL OUTBREAK;

D O I：

10.1186/s12879-017-2431-8

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background: The incidence of Proteus mirabilis antimicrobial resistance, especially that mediated by extended-spectrum beta-lactamases (ESBLs), has increased. We investigated the impact of ESBL production on the mortality of patients with P. mirabilis bacteremia in Korea. Methods: Patients diagnosed with P. mirabilis bacteremia between November 2005 and December 2013 at a 2000-bed tertiary care center in South Korea were included in this study. Phenotypic and molecular analyses were performed to assess ESBL expression. Characteristics and treatment outcomes were investigated among ESBL-producing and non-ESBL-producing P. mirabilis bacteremia groups. A multivariate analysis of 28-day mortality rates was performed to evaluate the independent impact of ESBLs. Results: Among 62 P. mirabilis isolates from 62 patients, 14 expressed ESBLs (CTX-M, 2; TEM, 5; both, 6; other, 1), and the 28-day mortality rate of the 62 patients was 17.74%. No clinical factor was significantly associated with ESBL production. The 28-day mortality rate in the ESBL-producing group was significantly higher than that in the non-ESBL-producing group (50% vs. 8.3%, p = 0.001). A multivariate analysis showed that ESBL production (odds ratio [OR], 11.53, 95% confidence interval [CI], 2.11-63.05, p = 0.005) was independently associated with the 28-day mortality rate in patients with P. mirabilis bacteremia. Conclusions: ESBL production is significantly associated with mortality in patients with bacteremia caused by P. mirabilis. Rapid detection of ESBL expression and prompt appropriate antimicrobial therapy are required to reduce mortality caused by P. mirabilis bacteremia.

引用

页数：10

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