Genetic Predictor to Identify Individuals With High Lipoprotein(a) Concentrations

被引:12
作者
Dron, Jacqueline S. [1 ,2 ,3 ,6 ]
Wang, Minxian [6 ]
Patel, Aniruddh P. [1 ,5 ,6 ,7 ]
Kartoun, Uri [8 ]
Ng, Kenney [8 ]
Hegele, Robert A. [2 ,3 ,4 ]
Khera, Amit V. [1 ,5 ,6 ,7 ]
机构
[1] Massachusetts Gen Hosp, Ctr Genom Med, 185 Cambridge St,CP7N 6-256, Boston, MA 02114 USA
[2] Western Univ, Robarts Res Inst, Schulich Sch Med & Dent, London, ON, Canada
[3] Western Univ, Dept Biochem, Schulich Sch Med & Dent, London, ON, Canada
[4] Western Univ, Dept Med, Schulich Sch Med & Dent, London, ON, Canada
[5] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA
[6] Broad Inst MIT & Harvard, Cardiovasc Dis Initiat, Cambridge, MA 02142 USA
[7] Harvard Med Sch, Dept Med, Boston, MA 02115 USA
[8] IBM Res, Ctr Computat Hlth, Cambridge, MA USA
基金
加拿大健康研究院;
关键词
biomarkers; cholesterol; genetic testing; genetics; humans;
D O I
10.1161/CIRCGEN.120.003182
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页数:3
相关论文
共 5 条
[1]   Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies A Mendelian Randomization Analysis [J].
Burgess, Stephen ;
Ference, Brian A. ;
Staley, James R. ;
Freitag, Daniel F. ;
Mason, Amy M. ;
Nielsen, Sune F. ;
Willeit, Peter ;
Young, Robin ;
Surendran, Praveen ;
Karthikeyan, Savita ;
Bolton, Thomas R. ;
Peters, James E. ;
Kamstrup, Pia R. ;
Tybjaerg-Hansen, Anne ;
Benn, Marianne ;
Langsted, Anne ;
Schnohr, Peter ;
Vedel-Krogh, Signe ;
Kobylecki, Camilla J. ;
Ford, Ian ;
Packard, Chris ;
Trompet, Stella ;
Jukema, J. Wouter ;
Sattar, Naveed ;
Di Angelantonio, Emanuele ;
Saleheen, Danish ;
Howson, Joanna M. M. ;
Nordestgaard, Borge G. ;
Butterworth, Adam S. ;
Danesh, John .
JAMA CARDIOLOGY, 2018, 3 (07) :619-627
[2]   The UK Biobank resource with deep phenotyping and genomic data [J].
Bycroft, Clare ;
Freeman, Colin ;
Petkova, Desislava ;
Band, Gavin ;
Elliott, Lloyd T. ;
Sharp, Kevin ;
Motyer, Allan ;
Vukcevic, Damjan ;
Delaneau, Olivier ;
O'Connell, Jared ;
Cortes, Adrian ;
Welsh, Samantha ;
Young, Alan ;
Effingham, Mark ;
McVean, Gil ;
Leslie, Stephen ;
Allen, Naomi ;
Donnelly, Peter ;
Marchini, Jonathan .
NATURE, 2018, 562 (7726) :203-+
[3]   The MELD-Plus: A generalizable prediction risk score in cirrhosis [J].
Kartoun, Uri ;
Corey, Kathleen E. ;
Simon, Tracey G. ;
Zheng, Hui ;
Aggarwal, Rahul ;
Ng, Kenney ;
Shaw, Stanley Y. .
PLOS ONE, 2017, 12 (10)
[4]   Lipoprotein(a) Reduction in Persons with Cardiovascular Disease [J].
Tsimikas, Sotirios ;
Karwatowska-Prokopczuk, Ewa ;
Gouni-Berthold, Ioanna ;
Tardif, Jean-Claude ;
Baum, Seth J. ;
Steinhagen-Thiessen, Elizabeth ;
Shapiro, Michael D. ;
Stroes, Erik S. ;
Moriarty, Patrick M. ;
Nordestgaard, Borge G. ;
Xia, Shuting ;
Guerriero, Jonathan ;
Viney, Nicholas J. ;
O'Dea, Louis ;
Witztum, Joseph L. .
NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (03) :244-255
[5]   Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores [J].
Vilhjalmsson, Bjarni J. ;
Yang, Jian ;
Finucane, Hilary K. ;
Gusev, Alexander ;
Lindstrom, Sara ;
Ripke, Stephan ;
Genovese, Giulio ;
Loh, Po-Ru ;
Bhatia, Gaurav ;
Do, Ron ;
Hayeck, Tristan ;
Won, Hong-Hee ;
Kathiresan, Sekar ;
Pato, Michele ;
Pato, Carlos ;
Tamimi, Rulla ;
Stahl, Eli ;
Zaitlen, Noah ;
Pasaniuc, Bogdan ;
Belbin, Gillian ;
Kenny, Eimear E. ;
Schierup, Mikkel H. ;
De Jager, Philip ;
Patsopouos, Nikolaos A. ;
Mc Carroll, Steve ;
Daly, Mark ;
Purce, Shaun ;
Chasman, Daniel ;
Neale, Benjamin ;
Goddard, Michael ;
Visscher, Peter M. ;
Kraft, Peter ;
Patterson, Nick ;
Price, Alkes L. .
AMERICAN JOURNAL OF HUMAN GENETICS, 2015, 97 (04) :576-592