Health-related quality of life in patients with cutaneous T-cell lymphoma?

被引:20
作者
Holahan, Heather M. [1 ]
Farah, Ronda S. [2 ]
Fitz, Sara [3 ]
Mott, Sarah L. [4 ]
Ferguson, Nkanyezi N. [5 ]
McKillip, Julie [5 ]
Link, Brian [6 ]
Liu, Vincent [5 ,7 ]
机构
[1] Univ Iowa Hosp & Clin, Rutgers New Jersey Med Sch, Dept Dermatol, Iowa City, IA 52242 USA
[2] Univ Minnesota, Dept Dermatol, Minneapolis, MN 55455 USA
[3] Med Associates Clin & Hlth Plans, Dubuque, IA USA
[4] Univ Iowa Hosp & Clin, Holden Comprehens Canc Ctr, Iowa City, IA 52242 USA
[5] Univ Iowa Hosp & Clin, Dept Dermatol, 40035 Pomerantz Family Pavil,200 Hawkins Dr, Iowa City, IA 52242 USA
[6] Univ Iowa Hosp & Clin, Dept Internal Med Hematol Oncol & Blood & Marrow, Iowa City, IA 52242 USA
[7] Univ Iowa Hosp & Clin, Dept Pathol, Iowa City, IA 52242 USA
关键词
SKIN-DISEASE; PSYCHOLOGICAL DISTRESS; UNITED-STATES; PSORIASIS; IMPACT; PREVALENCE; SEVERITY; SURVIVAL; BURDEN; RISK;
D O I
10.1111/ijd.14132
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
BackgroundLittle is currently known about health-related quality of life (HRQoL) of patients with cutaneous T-cell lymphoma (CTCL), a condition characterized by chronic, pruritic, visible lesions, features which may be uniquely influential. ObjectiveThe aim of this study was to establish baseline HRQoL data for patients with CTCL and identify its influencing factors. MethodsProspective, nonblinded survey design utilizing questionnaires including panels of QoL indices obtained from 105 patients with mycosis fungoides, Sezary syndrome, and CD30+ lymphoproliferative disorder. Chartreview correlated QoL with year of disease onset/diagnosis, type/stage of disease, current/past therapies, and medical/psychiatric diagnoses. ResultsPsychiatric condition was significantly associated with symptoms (P<0.01), emotions (P<0.01), and functioning (P<0.03) subscales along with overall composite measure (P<0.01). High-grade systemic therapy (OR=5.28) showed greater increase in odds of a lower health state than low grade (OR=1.54). The number of medical comorbidities was significantly related to itching (P<0.01). Increased age was a protective factor with respect to the emotions (P<0.01), functioning (P<0.01), and overall composite (P<0.01) but not predictive of symptoms. Lower income was associated with higher bother on the symptoms subscale. ConclusionsHRQoL in CTCL appears related to a number of factors, including presence of a psychiatric condition, use of systemic (particularly high grade) therapy, number of medical comorbidities, and income.
引用
收藏
页码:1314 / 1319
页数:6
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