Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration

被引：421

作者：

Ma, Liang ^{[1
]}

Li, Ying ^{[1
]}

Peng, Junya ^{[1
]}

Wu, Danni ^{[1
]}

Zhao, Xiaoxin ^{[1
]}

Cui, Yitong ^{[1
]}

Chen, Lilian ^{[1
]}

Yan, Xiaojun ^{[2
]}

Du, Yanan ^{[2
,3
]}

Yu, Li ^{[1
]}

机构：

[1] Tsinghua Univ, Peking Univ, Sch Life Sci, Joint Ctr Life Sci,State Key Lab Biomembrane & Me, Beijing 100084, Peoples R China

[2] Tsinghua Univ, Sch Med, Dept Biomed Engn, Beijing 100084, Peoples R China

[3] Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310003, Zhejiang, Peoples R China

来源：

CELL RESEARCH | 2015年 / 25卷 / 01期

基金：

中国国家自然科学基金;

关键词：

migrasome; migracytosis; migration; retraction fibers; vesicle; VESICLE FORMATION; SECRETION; EXOCYTOSIS; INHIBITOR; EXOSOMES; FORM;

D O I：

10.1038/cr.2014.135

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cells communicate with each other through secreting and releasing proteins and vesicles. Many cells can migrate. In this study, we report the discovery of migracytosis, a cell migration-dependent mechanism for releasing cellular contents, and migrasomes, the vesicular structures that mediate migracytosis. As migrating cells move, they leave long tubular strands, called retraction fibers, behind them. Large vesicles, which contain numerous smaller vesicles, grow on the tips and intersections of retraction fibers. These fibers, which connect the vesicles with the main cell body, eventually break, and the vesicles are released into the extracellular space or directly taken up by surrounding cells. Since the formation of these vesicles is migration-dependent, we named them "migrasomes". We also found that cytosolic contents can be transported into migrasomes and released from the cell through migrasomes. We named this migration-dependent release mechanism "migracytosis".

引用

页码：24 / 38

页数：15

共 11 条

[1] Inhibition of pancreatic adenocarcinoma cellular invasiveness by blebbistatin: a novel myosin II inhibitor [J].