Enantio- and diastereoselective Ir-catalyzed allylic substitutions for asymmetric synthesis of amino acid derivatives

被引：154

作者：

Kanayama, T ^{[1
]}

Yoshida, K ^{[1
]}

Miyabe, H ^{[1
]}

Takemoto, Y ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 606, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 18期

关键词：

allylation; amino acids; enantioselectivity; iridium; P ligands;

D O I：

10.1002/anie.200250654

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Simply switching the base employed in the first enantioselective allylic substitutions of diphenylimino glycinate 1 with 2, which are catalyzed by an Ir complex of chiral phosphite 5, allows the two branched diastereomers 3 and 4 to be selectively synthesized with little or no formation of linear substitution products.

引用

页码：2054 / 2056

页数：3

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