Identification of novel interactors of human telomeric G-quadruplex DNA

被引：33

作者：

Pagano, Bruno ^{[1
]}

Margarucci, Luigi ^{[2
]}

Zizza, Pasquale ^{[3
]}

Amato, Jussara ^{[1
]}

Iaccarino, Nunzia ^{[1
]}

Cassiano, Chiara ^{[2
]}

Salvati, Erica ^{[3
]}

Novellino, Ettore ^{[1
]}

Biroccio, Annamaria ^{[3
]}

Casapullo, Agostino ^{[2
]}

Randazzo, Antonio ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Pharm, I-80131 Naples, Italy

[2] Univ Salerno, Dept Pharm, I-84084 Fisciano, SA, Italy

[3] Regina Elena Inst Canc Res, Expt Chemotherapy Lab, I-00158 Rome, Italy

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 14期

关键词：

SECONDARY STRUCTURES; HUMAN-CHROMOSOMES; PROTEIN; PROMOTER; POLYMORPHISM; EXTENSION; SEQUENCE; END;

D O I：

10.1039/c4cc07231f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A chemoproteomic-driven approach was used to investigate the interaction network between human telomeric G-quadruplex DNA and nuclear proteins. We identified novel G-quadruplex binding partners, able to recognize these DNA structures at chromosome ends, suggesting a possible, and so far unknown, role of these proteins in telomere functions.

引用

页码：2964 / 2967

页数：4

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