Identification of novel interactors of human telomeric G-quadruplex DNA

被引：33

作者：

Pagano, Bruno ^{[1
]}

Margarucci, Luigi ^{[2
]}

Zizza, Pasquale ^{[3
]}

Amato, Jussara ^{[1
]}

Iaccarino, Nunzia ^{[1
]}

Cassiano, Chiara ^{[2
]}

Salvati, Erica ^{[3
]}

Novellino, Ettore ^{[1
]}

Biroccio, Annamaria ^{[3
]}

Casapullo, Agostino ^{[2
]}

Randazzo, Antonio ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Pharm, I-80131 Naples, Italy

[2] Univ Salerno, Dept Pharm, I-84084 Fisciano, SA, Italy

[3] Regina Elena Inst Canc Res, Expt Chemotherapy Lab, I-00158 Rome, Italy

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 14期

关键词：

SECONDARY STRUCTURES; HUMAN-CHROMOSOMES; PROTEIN; PROMOTER; POLYMORPHISM; EXTENSION; SEQUENCE; END;

D O I：

10.1039/c4cc07231f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A chemoproteomic-driven approach was used to investigate the interaction network between human telomeric G-quadruplex DNA and nuclear proteins. We identified novel G-quadruplex binding partners, able to recognize these DNA structures at chromosome ends, suggesting a possible, and so far unknown, role of these proteins in telomere functions.

引用

页码：2964 / 2967

页数：4

共 38 条

[1] Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?
Balasubramanian, Shankar
Hurley, Laurence H.
Neidle, Stephen
[J]. NATURE REVIEWS DRUG DISCOVERY, 2011, 10 (04) : 261 - 275
[2] Biffi G, 2013, NAT CHEM, V5, P182, DOI [10.1038/NCHEM.1548, 10.1038/nchem.1548]
[3] DNA secondary structures: stability and function of G-quadruplex structures
Bochman, Matthew L.
Paeschke, Katrin
Zakian, Virginia A.
[J]. NATURE REVIEWS GENETICS, 2012, 13 (11) : 770 - 780
[4] Quadruplex DNA: sequence, topology and structure
Burge, Sarah
Parkinson, Gary N.
Hazel, Pascale
Todd, Alan K.
Neidle, Stephen
[J]. NUCLEIC ACIDS RESEARCH, 2006, 34 (19) : 5402 - 5415
[5] In cell scalaradial interactome profiling using a bio-orthogonal clickable probe
Cassiano, C.
Margarucci, L.
Esposito, R.
Riccio, R.
Tosco, A.
Casapullo, A.
Monti, M. C.
[J]. CHEMICAL COMMUNICATIONS, 2014, 50 (45) : 6043 - 6045
[6] Structural polymorphism within a regulatory element of the human KRAS promoter:: formation of G4-DNA recognized by nuclear proteins
Cogoi, Susanna
Paramasivam, Manikandan
Spolaore, Barbara
Xodo, Luigi E.
[J]. NUCLEIC ACIDS RESEARCH, 2008, 36 (11) : 3765 - 3780
[7] Polymorphism of human telomeric quadruplex structures
Dai, Jixun
Carver, Megan
Yang, Danzhou
[J]. BIOCHIMIE, 2008, 90 (08) : 1172 - 1183
[8] Shelterin: the protein complex that shapes and safeguards human telomeres
de Lange, T
[J]. GENES & DEVELOPMENT, 2005, 19 (18) : 2100 - 2110
[9] DNA secondary structures and epigenetic determinants of cancer genome evolution
De, Subhajyoti
Michor, Franziska
[J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2011, 18 (08) : 950 - U115
[10] Lamin B1 fluctuations have differential effects on cellular proliferation and senescence
Dreesen, Oliver
Chojnowski, Alexandre
Ong, Peh Fern
Zhao, Tian Yun
Common, John E.
Lunny, Declan
Lane, E. Birgitte
Lee, Shu Jin
Vardy, Leah A.
Stewart, Colin L.
Colman, Alan
[J]. JOURNAL OF CELL BIOLOGY, 2013, 200 (05) : 605 - 617

← 1 2 3 4 →