Prevention of parenteral nutrition-associated liver disease: lipid minimization

被引：81

作者：

Cober, M. Petrea ^{[1
,5
]}

Teitelbaum, Daniel H. ^{[2
,3
,4
]}

机构：

[1] Univ Michigan, Univ Michigan Hosp, Dept Pharm, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Univ Michigan Hosp, Dept Surg, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Ctr Hlth, Ann Arbor, MI 48109 USA

[4] Univ Michigan, CS Mott Childrens Hosp, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Coll Pharm, Ann Arbor, MI 48109 USA

来源：

CURRENT OPINION IN ORGAN TRANSPLANTATION | 2010年 / 15卷 / 03期

关键词：

cholestasis; lipid emulsions and essential fatty acids; parenteral nutrition; SHORT-BOWEL SYNDROME; FISH-OIL; MOUSE MODEL; CHOLESTASIS; CHILDREN; FAT; TRANSPLANTATION; COMPLICATIONS; EMULSIONS; INFUSION;

D O I：

10.1097/MOT.0b013e328338c2da

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

Purpose of review The cause of parenteral nutrition-associated liver disease (PNALD) is unknown. Evidence over the past decade has suggested soybean oil-based intravenous emulsions are a contributing factor to the development of PNALD. Recent findings This review details the historical and scientific rationale, which associates intravenous lipid emulsion administration and PNALD. The article then reviews our own group's experience with lipid restriction and the reversal of PNALD in neonates on long-term parenteral nutrition. Finally, a clinical approach to restricting soybean-based intravenous lipid emulsions in parenteral nutrition is given. Summary An association between intravenous lipid emulsion administration and the development of PNALD seems probable. Strategies to reduce lipid emulsions or develop new, nonsoybean-based lipid emulsions should be considered.

引用

页码：330 / 333

页数：4

共 28 条

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