Serum levels of anti-PF4 IgG after AZD1222 (ChAdOx1 nCoV-19) vaccination

被引：5

作者：

Cohen, Taylor S. ^{[1
]}

Kelly, Elizabeth J. ^{[2
]}

Nylander, Sven ^{[3
]}

Bansal, Himanshu ^{[4
]}

Jepson, Brett M. ^{[4
]}

Bhuyan, Prakash ^{[5
]}

Sobieszczyk, Magdalena E. ^{[6
]}

Falsey, Ann R. ^{[7
]}

机构：

[1] Astrazeneca, Microbiome Discovery Vaccines & Immune Therapies, BioPharmaceut R&D, Gaithersburg, MD 20878 USA

[2] AstraZeneca, Translat Med Vaccines & Immune Therapies, BioPharmaceut R&D, Gaithersburg, MD USA

[3] AstraZeneca, Biopharmaceut R&D, Clin Dev Vaccines & Immune Therapies, Gothenburg, Sweden

[4] AstraZeneca, BioPharmaceut R&D, Biometr Vaccines & Immune Therapies, Gaithersburg, MD USA

[5] AstraZeneca, BioPharmaceut R&D, Vaccines & Immune Therapies, Gaithersburg, MD USA

[6] Columbia Univ, Dept Med, Div Infect Dis, Irving Med Ctr & New York Presbyter, New York, NY USA

[7] Univ Rochester, Med Ctr, Rochester, NY 14642 USA

来源：

SCIENTIFIC REPORTS | 2022年 / 12卷 / 01期

关键词：

FACTOR 4/HEPARIN ANTIBODIES; THROMBOCYTOPENIA; DIAGNOSIS;

D O I：

10.1038/s41598-022-11623-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Rare cases of thrombosis with thrombocytopenia syndrome (TTS) have been reported after AZD1222. Anti-platelet factor-4 (PF4) antibodies were observed in patients following presentation of TTS, however it is unclear if AZD1222 was responsible for inducing production of anti-PF4. Paired samples (baseline and day-15) from a phase 3 trial of AZD1222 vs placebo were analyzed for anti-PF4 levels; 19/1727 (1.1%, AZD1222) vs 7/857 (0.8%, placebo) participants were anti-PF4-IgG-negative at baseline but had moderate Day-15 levels (P = 0.676) and 0/35 and 1/20 (5.0%) had moderate levels at baseline but high Day-15 levels. These data indicate that AZD1222 does not induce a clinically relevant general increase in anti-PF4 IgG.

引用

页数：5

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